Showing 25 of 26 results

• Publication

  released

  Single-cell gene expression and chromatin accessibility profiling of human pancreatic islets at basal and stimulatory conditions nominates mechanisms of type 1 diabetes genetic risk

  Ricardo D’Oliveira Albanus, Xuming Tang, Henry J. Taylor, et al.

  bioRxiv. 2022-11-14;

  • doi:10.1101/2022.11.12.516291

• Publication

  released

  Characterizing cis-regulatory elements using single-cell epigenomics

  Sebastian Preissl, Kyle J Gaulton, Bing Ren.

  Nat Rev Genet. 2022-07-15;

  • doi:10.1038/s41576-022-00509-1
  • PMID:35840754

• Publication

  released

  A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures

  Arushi Varshney, Yasuhiro Kyono, Venkateswaran Ramamoorthi Elangovan, et al.

  Diabetes. 2021-04-13;(db201087)

  • doi:10.2337/db20-1087
  • PMID:33849996

• Publication

  released

  Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

  Benjamin H. Mullin, Jennifer Tickner, Kun Zhu, et al.

  Genome Biology. 2020-03-26;20(1):80.

  • PMID:32216834
  • PMCID:PMC7098081
  • doi:10.1186/s13059-020-01997-2

  URL: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-01997-2

• Publication

  released

  CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

  Ruilin Tian, Mariam A Gachechiladze, Connor H Ludwig, et al.

  Neuron. 2019-10-23;104(2):239-255.e12.

  • doi:10.1016/j.neuron.2019.07.014
  • PMID:31422865
  • PMCID:PMC6813890

• Publication

  released

  The single-cell transcriptomic landscape of early human diabetic nephropathy

  Parker C Wilson, Haojia Wu, Yuhei Kirita, et al.

  Proc Natl Acad Sci U S A. 2019-09-24;116(39):19619-19625.

  • PMID:31506348
  • PMCID:PMC6765272
  • doi:10.1073/pnas.1908706116

• Publication

  released

  Exploring genetic interaction manifolds constructed from rich single-cell phenotypes

  Thomas M Norman, Max A Horlbeck, Joseph M Replogle, et al.

  Science. 2019-08-23;365(6455):786-793.

  • doi:10.1126/science.aax4438
  • PMID:31395745
  • PMCID:PMC6746554

• Publication

  released

  Functional testing of thousands of osteoarthritis-associated variants for regulatory activity

  Jason C Klein, Aidan Keith, Sarah J Rice, et al.

  Nat Commun. 2019-06-04;10(1):2434.

  • doi:10.1038/s41467-019-10439-y
  • PMID:31164647
  • PMCID:PMC6547687

• Publication

  released

  Charting cellular identity during human in vitro β-cell differentiation

  Adrian Veres, Aubrey L Faust, Henry L Bushnell, et al.

  Nature. 2019-05-01;569(7756):368-373.

  • doi:10.1038/s41586-019-1168-5
  • PMCID:PMC6903417
  • PMID:31068696

• Publication

  released

  Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes

  Yongxu Zhao, Zhuanghui Feng, Yongxian Zhang, et al.

  Cell Rep. 2019-01-22;26(4):884-892.e4.

  • doi:10.1016/j.celrep.2018.12.100
  • PMID:30673611

• Publication

  released

  High-throughput characterization of genetic effects on DNA-protein binding and gene transcription

  Cynthia A Kalita, Christopher D Brown, Andrew Freiman, et al.

  Genome Res. 2018-09-25;28(11):1701-1708.

  • doi:10.1101/gr.237354.118
  • PMID:30254052
  • PMCID:PMC6211638

• Publication

  released

  Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells

  Tahsin Stefan Barakat, Florian Halbritter, Man Zhang, et al.

  Cell Stem Cell. 2018-08-02;23(2):276-288.e8.

  • doi:10.1016/j.stem.2018.06.014
  • PMID:30033119
  • PMCID:PMC6084406

• Publication

  released

  Single-cell RNA-seq analysis reveals the progression of human osteoarthritis

  Quanbo Ji, Yuxuan Zheng, Guoqiang Zhang, et al.

  Ann Rheum Dis. 2018-07-19;78(1):100-110.

  • doi:10.1136/annrheumdis-2017-212863
  • PMID:30026257
  • PMCID:PMC6317448

• Publication

  released

  Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey

  Cassandra N Spracklen, Jinxiu Shi, Swarooparani Vadlamudi, et al.

  PLoS Genet. 2018-04-05;14(4):e1007275.

  • doi:10.1371/journal.pgen.1007275
  • PMID:29621232
  • PMCID:PMC5886383

• Publication

  released

  A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression

  Ina Kycia, Brooke N Wolford, Jeroen R Huyghe, et al.

  Am J Hum Genet. 2018-04-05;102(4):620-635.

  • doi:10.1016/j.ajhg.2018.02.020
  • PMID:29625024
  • PMCID:PMC5985342

• Publication

  released

  Integrative analysis of super enhancer SNPs for type 2 diabetes

  Weiping Sun, Sihong Yao, Jielong Tang, et al.

  PLoS One. 2018-01-31;13(1):e0192105.

  • doi:10.1371/journal.pone.0192105
  • PMCID:PMC5792005
  • PMID:29385209

• Publication

  released

  Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

  Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, et al.

  Nat Commun. 2018-01-22;9(1):321.

  • doi:10.1038/s41467-017-02380-9
  • PMID:29358691
  • PMCID:PMC5778074

• Publication

  released

  Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes

  Jeremy R B Newman, Ana Conesa, Matthew Mika, et al.

  Genome Res. 2017-11-01;27(11):1807-1815.

  • doi:10.1101/gr.217984.116
  • PMCID:PMC5668939
  • PMID:29025893

• Publication

  released

  Data of methylome and transcriptome derived from human dilated cardiomyopathy

  Bong-Seok Jo, In-Uk Koh, Jae-Bum Bae, et al.

  Data Brief. 2016-09-14;9:382-387.

  • doi:10.1016/j.dib.2016.09.006
  • PMID:27699191
  • PMCID:PMC5035344

• Publication

  released

  Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort

  Zhuo Chen, Feng Miao, Andrew D Paterson, et al.

  Proc Natl Acad Sci U S A. 2016-05-24;113(21):E3002-11.

  • doi:10.1073/pnas.1603712113
  • PMID:27162351
  • PMCID:PMC4890596

• Publication

  released

  Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types

  Jin Li, Johanna Klughammer, Matthias Farlik, et al.

  EMBO Rep. 2016-02-17;17(2):178-87.

  • doi:10.15252/embr.201540946
  • PMCID:PMC4784001
  • PMID:26691212

• Publication

  released

  Integrative analysis of methylome and transcriptome in human blood identifies extensive sex- and immune cell-specific differentially methylated regions

  Shimrat Mamrut, Nili Avidan, Elsebeth Staun-Ram, et al.

  Epigenetics. 2015-10-09;10(10):943-57.

  • doi:10.1080/15592294.2015.1084462
  • PMID:26291385
  • PMCID:PMC4844205

• Publication

  released

  Research resource: the pdx1 cistrome of pancreatic islets

  Cynthia Khoo, Juxiang Yang, Samuel A Weinrott, et al.

  Mol Endocrinol. 2012-03-01;26(3):521-33.

  • doi:10.1210/me.2011-1231
  • PMCID:PMC3286194
  • PMID:22322596

• Publication

  released

  A map of open chromatin in human pancreatic islets

  Kyle J Gaulton, Takao Nammo, Lorenzo Pasquali, et al.

  Nature Genetics. 2010-01-01;42(3):255–259.

  • PMID:20118932
  • doi:10.1038/ng.530

• Publication

  released

  The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity

  Jose M Mellado-Gil, Esther Fuente-Martín, Petra I Lorenzo, et al.

  Cell Death Dis. 2018-02-15;9(3):279.

  • doi:10.1038/s41419-018-0272-z
  • PMID:29449530
  • PMCID:PMC5833347