Search – Common Metabolic Diseases Genome Atlas

Showing 20 of 20 results

Publication
released
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes
Fan Zhang, Anna Helena Jonsson, Aparna Nathan, et al.
Nature. 2023-11-08;623(7987):616-624.
URL: https://doi.org/10.7303/syn52297840
Data summary: CITE-seq single-cell expression matrices and sequencing and bulk expression matrices are available…
URL: https://arkportal.synapse.org/Explore/Datasets/DetailsPage?id=syn52297840
Data summary: Associated genotype and clinical data are available through the Arthritis and Autoimmune and…
URL: https://immunogenomics.io/ampra2/
Data summary: A cell browser website is available to visualize our data and results.
Data summary: AMP Phase 1 single-cell data from ref. 8 are available on Immport (SDY998). PEAC clinical trial…
URL: https://github.com/Immunogenomics/RA_Atlas_CITEseq/
Data summary: The source code for the analyses is available at GitHub
URL: https://zenodo.org/record/8118599
Data summary: The source code for the analyses is available at zenodo
Publication
released
Single-cell gene expression and chromatin accessibility profiling of human pancreatic islets at basal and stimulatory conditions nominates mechanisms of type 1 diabetes genetic risk
Ricardo D’Oliveira Albanus, Xuming Tang, Henry J. Taylor, et al.
bioRxiv. 2022-11-14;
- doi:10.1101/2022.11.12.516291
Publication
released
Cohesin-mediated loop anchors confine the locations of human replication origins
Daniel J Emerson # 1 2 3 , Peiyao A Zhao # 4 , Ashley L Cook # 1 2 3 , et al.
Nature. 2022-06-08;606(7915):812-819.
Data summary: All new raw data created in this manuscript have been uploaded to the 4D Nucleome portal and will…
Publication
released
Cryomilling Tethered Chromatin Conformation Capture reveal new insights into inter-chromosomal interactions
Jiang Xu, Sanjeev Kumar, Nan Hua, et al.
bioRxiv. 2022-02-12;
- doi:10.1101/2022.02.03.478915
Publication
released
Systematic analysis of binding of transcription factors to noncoding variants
Jian Yan, Yunjiang Qiu, André M. Ribeiro dos Santos, et al.
Nature. 2021-1-27;
- doi:10.1038/s41586-021-03211-0
- PMID:33505025
Publication
released
Large-scale genetic association and single cell accessible chromatin mapping defines cell type-specific mechanisms of type 1 diabetes risk
Joshua Chiou, Ryan J Geusz, Mei-Lin Okino, et al.
Nature. 2021-05-19;594(7863):398-402.
- doi:10.1038/s41586-021-03552-w
- PMID:34012112
Publication
released
Genome-wide enhancer maps link risk variants to disease genes
Joseph Nasser, Drew T. Bergman, Charles P. Fulco, et al.
Nature. 2021-04-07;593:238–243.
- doi:10.1038/s41586-021-03446-x
Publication
released
Regulatory genomic circuitry of human disease loci by integrative epigenomics
Carles A Boix, Benjamin T James, Yongjin P Park, et al.
Nature. 2021-02-03;590(7845):300-307.
Publication
released
Expanded encyclopaedias of DNA elements in the human and mouse genomes
The ENCODE Project Consortium, Jill E. Moore, Michael J. Purcaro, et al.
Nature. 2020-07-29;583(7818):699–710.
Publication
released
Index and biological spectrum of human DNase I hypersensitive sites
Wouter Meuleman, Alexander Muratov, Eric Rynes, et al.
Nature. 2020-07-29;584(7820):244–251.
Publication
released
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
C.C. Robertson, J.R.J. Inshaw, S. Onengut-Gumuscu, et al.
bioRxiv. 2020-06-20;
- doi:10.1101/2020.06.19.158071
Publication
released
Charting cellular identity during human in vitro β-cell differentiation
Adrian Veres, Aubrey L Faust, Henry L Bushnell, et al.
Nature. 2019-05-01;569(7756):368-373.
Publication
released
Integrative analysis of haplotype-resolved epigenomes across human tissues
Danny Leung, Inkyung Jung, Nisha Rajagopal, et al.
Nature. 2015-02-19;518(7539):350-354.
Publication
released
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
Ida Moltke, Niels Grarup, Marit E Jørgensen, et al.
Nature. 2014-08-14;512(7513):190-3.
- doi:10.1038/nature13425
- PMID:25043022
Publication
released
Transcriptome and genome sequencing uncovers functional variation in humans
Tuuli Lappalainen, Michael Sammeth, Marc R Friedländer, et al.
Nature. 2013-09-26;501(7468):506-11.
Publication
released
Biological, clinical and population relevance of 95 loci for blood lipids
Tanya M Teslovich, Kiran Musunuru, Albert V Smith, et al.
Nature. 2010-08-05;466(7307):707-13.
URL: http://csg.sph.umich.edu/willer/public/lipids2010/
Publication
released
Parental origin of sequence variants associated with complex diseases
Augustine Kong, Valgerdur Steinthorsdottir, Gisli Masson, et al.
Nature. 2009-12-17;462(7275):868-74.
Publication
released
The three-dimensional chromatin structure of the major human pancreatic cell types reveals lineage-specific regulatory architecture of T2D risk
Chun Su, Long Gao, Catherine L. May, et al.
bioRxiv.
- doi:10.1101/2021.11.30.470653
Publication
released
Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex trait variants using single nucleus ATAC-seq
Paola Benaglio, Jacklyn Newsome, Jee Yun Han, et al.
bioRxiv.
- doi:10.1101/2020.12.03.387894
Publication
released
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
Xin Sheng, Ziyuan Ma, Junnan Wu, et al.
bioRxiv.
- doi:10.1101/2020.11.09.375592