September 2021 Data Release

We are pleased to release common metabolic disease relevant datasets:

•  Kidney Datasets from Katalin Susztak Lab
• ATAC-seq and Capture-C data from Struan Grant Lab 

       Datasets from publications

• Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

• Parental origin of sequence variants associated with complex diseases

• Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population

• A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

• Global Genomic And Transcriptomic Analysis Of Human Pancreatic Islets Reveals Novel Genes Influencing Glucose Metabolism

• FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

• Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

• The Genetic Regulatory Signature Of Type 2 Diabetes In Human Skeletal Muscle

• Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

• Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver

• Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue

• Mapping the genetic architecture of gene expression in human liver

•  Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

•  Genetic Regulatory Signatures Underlying Islet Gene Expression And Type 2 Diabetes

• A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response

• Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

• A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes

• Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

• Integration Of Human Pancreatic Islet Genomic Data Refines Regulatory Mechanisms At Type 2 Diabetes Susceptibility Loci

• The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity

• Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey

• A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression

• Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

• Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

• Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

• Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes

• Human Pancreatic Islet Three-dimensional Chromatin Architecture Provides Insights into The Genetics of Type 2 Diabete

• Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

• Biological, clinical and population relevance of 95 loci for blood lipids

• Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

• Glucose-Induced Changes in Gene Expression in Human Pancreatic Islets: Causes or Consequences of Chronic Hyperglycemia

• Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

• Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk

• Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation

• Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

• Biological, clinical and population relevance of 95 loci for blood lipids

• Glucose-Induced Changes in Gene Expression in Human Pancreatic Islets: Causes or Consequences of Chronic Hyperglycemia

• Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics

• Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors

• Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

• Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes

• Systematic analysis of binding of transcription factors to noncoding variants

• Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression

• Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome

• A molecular quantitative trait locus map for osteoarthritis

• Single-Cell Transcriptome Analysis Maps the Developmental Track of the Human Heart

• Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle

• Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction