Type 2 diabetes mellitus affects 1 in 10 Americans and is influenced by many genetic factors. In the proposed study we will identify non-coding genetic factors causal for diabetes risk that affect the expression of a transcription factor gene in diabetes-relevant tissues, and characterize the genomic network regulated by these transcription factors. Results from the study will uncover critical cellular gene networks dysregulated in diabetes pathogenesis, and facilitate development of novel therapies.