Search – Common Metabolic Diseases Genome Atlas

Showing 14 of 130 results

Publication
released
An encyclopedia of human enhancer-gene regulatory interactions
Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, et al.
Nature. 2026-07-15;
- PMID:42457959
- doi:10.1038/s41586-026-10781-4
Publication
released
Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2
Sheridan H Littleton, Khanh B Trang, Christina M Volpe, et al.
Cell Genomics. 2024-05-08;
Data summary: Hi-C, RNA-seq, ATAC-seq, single-nucleus RNA-seq, and single-nucleus ATAC-seq data have been…
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241592
Data summary: Raw and processed Hi-C data GEO: GSE241592
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241050
Data summary: Raw and processed RNA-seq data GEO: GSE241050
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241591
Data summary: Raw and processed ATAC-seq data GEO: GSE241591
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241594
Data summary: Raw and processed single-nucleus RNA-seq data GEO: GSE241594
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241593
Data summary: Raw and processed single-nucleus ATAC-seq data GEO: GSE241593;
Publication
released
Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk
Nicole E Kramer, Philip Coryell, Susan D'Costa, et al.
bioRvix. 2024-05-05;
- doi:10.1101/2024.05.05.592567
Publication
released
An integrated map of cell type-specific gene expression in pancreatic islets
Ruth M Elgamal, Parul Kudtarkar, Rebecca L Melton, et al.
Diabetes. 2023-15-08;(db230130)
- PMID:37582230
- doi:10.2337/db23-0130
Publication
released
Population-scale skeletal muscle single-nucleus multi-omic profiling reveals extensive context specific genetic regulation
Arushi Varshney Arushi Varshney, Nandini Manickam, Peter Orchard, et al.
bioRxiv. 2023-12-15;
URL: https://www.biorxiv.org/content/10.1101/2023.12.15.571696v2
Publication
released
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions
Renhe Luo, Jielin Yan, Jin Woo Oh, et al.
at Genet. 2023-07-24;55(8):1336-1346.
- doi:10.1038/s41588-023-01450-7
- PMID:37488417
Available supplemental data: website
Data summary: The parental HUES8 hESC line was obtained from Harvard University under a material transfer…
Publication
released
Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes
Kristina M. Garske, Asha Kar, Caroline Comenho, et al.
Nat Commun. 2023-07-14;14(1):4214.
Publication
released
Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture
Linda Kachuri, Angel C. Y. Mak, Donglei Hu, et al.
Nat Genet. 2023-05-25;55(6):952-963.
Publication
released
Lineage-specific differences and regulatory networks governing human chondrocyte development
Daniel Richard, Steven Pregizer, Divya Venkatasubramanian, et al.
Elife. 2023-03-15;15:12:e79925
Publication
released
Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines
Paola Benaglio, Han Zhu, Mei-Lin Okino, et al.
Cell Genomics. 2022-12-14;2(12):100214.
Publication
released
Characterizing cis-regulatory elements using single-cell epigenomics
Sebastian Preissl, Kyle J Gaulton, Bing Ren.
Nat Rev Genet. 2022-07-15;
- doi:10.1038/s41576-022-00509-1
- PMID:35840754
Publication
released
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
Hongbo Liu, Tomohito Doke, Dong Guo, et al.
Nature Genetics. 2022-06-16;54:950–962.
- PMID:35710981
- doi:10.1038/s41588-022-01097-w
Available supplemental data: website
URL: https://github.com/hbliu/Kidney_Epi_Pri
Data summary: Customized code used in the present study is available at github
Available supplemental data: website
URL: https://doi.org/10.5281/zenodo.6392494
Data summary: Zenodo
Publication
released
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells
Kousuke Mouri, Michael H. Guo, Carl G. de Boer, et al.
Nat Genet. 2022-05-01;54(5):603-612.
- doi:10.1038/s41588-022-01056-5
- PMID:35513721
Publication
released
A single-cell atlas of human and mouse white adipose tissue
Margo P. Emont, Christopher Jacobs, Adam L. Essene, et al.
Nature. 2022-03-16;603(7903):926-933.
URL: https://www.nature.com/articles/s41586-022-04518-2