Showing 15 of 267 results

• Publication

  released

  Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants

  Thomsen SK, Ceroni A, van de Bunt M, et al.

  December 2016;(65(12)):3805-3811.

  • PMID:27554474
  • doi:10.2337/db16-0361

• Publication

  released

  An encyclopedia of human enhancer-gene regulatory interactions

  Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, et al.

  Nature. 2026-07-15;

  • PMID:42457959
  • doi:10.1038/s41586-026-10781-4

• Publication

  released

  GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density

  Mitchell Conery, James A. Pippin, Yadav Wagley, et al.

  Genome Biology. 2025-10-03;26(1):331.

  • PMID:41044600
  • doi:10.1186/s13059-025-03802-4
  • PMCID:PMC12492525

• Publication

  released

  A comprehensive spatio-cellular map of the human hypothalamus

  John A. Tadross, Lukas Steuernagel, Georgina K. C. Dowsett, et al.

  Nature. 2025-02-05;639(8055):708-716.

  • doi:10.1038/s41586-024-08504-8
  • PMID:39910307
  • PMCID:PMC11922758

  URL: https://www.nature.com/articles/s41586-024-08504-8

• Publication

  released

  Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2

  Sheridan H Littleton, Khanh B Trang, Christina M Volpe, et al.

  Cell Genomics. 2024-05-08;

  • doi:10.1101/2023.08.21.553157
  • PMID:37662342
  • PMCID:PMC10473629

  Data summary: Hi-C, RNA-seq, ATAC-seq, single-nucleus RNA-seq, and single-nucleus ATAC-seq data have been…See more

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241592

  Data summary: Raw and processed Hi-C data GEO: GSE241592

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241050

  Data summary: Raw and processed RNA-seq data GEO: GSE241050

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241591

  Data summary: Raw and processed ATAC-seq data GEO: GSE241591

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241594

  Data summary: Raw and processed single-nucleus RNA-seq data GEO: GSE241594

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241593

  Data summary: Raw and processed single-nucleus ATAC-seq data GEO: GSE241593;

• Publication

  released

  Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

  Nicole E Kramer, Philip Coryell, Susan D'Costa, et al.

  bioRvix. 2024-05-05;

  • doi:10.1101/2024.05.05.592567

• Publication

  released

  An integrated map of cell type-specific gene expression in pancreatic islets

  Ruth M Elgamal, Parul Kudtarkar, Rebecca L Melton, et al.

  Diabetes. 2023-15-08;(db230130)

  • PMID:37582230
  • doi:10.2337/db23-0130

• Publication

  released

  Population-scale skeletal muscle single-nucleus multi-omic profiling reveals extensive context specific genetic regulation

  Arushi Varshney Arushi Varshney, Nandini Manickam, Peter Orchard, et al.

  bioRxiv. 2023-12-15;

  • PMID:38168419
  • PMCID:PMC10760134
  • doi:10.1101/2023.12.15.571696

  URL: https://www.biorxiv.org/content/10.1101/2023.12.15.571696v2

• Publication

  released

  A comparative atlas of single-cell chromatin accessibility in the human brain

  Yang Eric Li, Sebastian Preissl, Michael Miller, et al.

  Science. 2023-10-13;382(6667)

  • doi:10.1126/science.adf7044
  • PMID:37824643
  • PMCID:PMC10852054

• Publication

  released

  Plasma proteomic associations with genetics and health in the UK Biobank

  Benjamin B Sun, Joshua Chiou, Matthew Traylor, et al.

  Nature. 2023-10-04;622(7982):329-338.

  • doi:10.1038/s41586-023-06592-6
  • PMID:37794186
  • PMCID:PMC10567551

  URL: http://ukb-ppp.gwas.eu

  Data summary: Proteo-genomic results and summary association data are available through an interactive portal.

  URL: https://www.ukbiobank.ac.uk/enable-your-research

  Data summary: Underlying NPX measures are available through the UK Biobank Research Analysis Portal.

  URL: https://biobank.ndph.ox.ac.uk/showcase/label.cgi?id=1839

  Data summary: UKB has catalogued the dataset in Category 1839, under ‘Field 30900’, described in greater detail…See more

• Publication

  released

  Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions

  Renhe Luo, Jielin Yan, Jin Woo Oh, et al.

  at Genet. 2023-07-24;55(8):1336-1346.

  • doi:10.1038/s41588-023-01450-7
  • PMID:37488417

  Available supplemental data: website

  Data summary: The parental HUES8 hESC line was obtained from Harvard University under a material transfer…See more

• Publication

  released

  An atlas of healthy and injured cell states and niches in the human kidney

  Blue B. Lake, Rajasree Menon, Seth Winfree, et al.

  Nature. 2023-07-19;619(7970):585-594.

  • doi:10.1038/s41586-023-05769-3
  • PMID:37468583
  • PMCID:PMC10356613

  URL: https://www.nature.com/articles/s41586-023-05769-3

• Publication

  released

  Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes

  Kristina M. Garske, Asha Kar, Caroline Comenho, et al.

  Nat Commun. 2023-07-14;14(1):4214.

  • doi:10.1038/s41467-023-39919-y
  • PMID:37452040
  • PMCID:PMC10349101

• Publication

  released

  Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture

  Linda Kachuri, Angel C. Y. Mak, Donglei Hu, et al.

  Nat Genet. 2023-05-25;55(6):952-963.

  • PMID:37231098
  • doi:10.1038/s41588-023-01377-z
  • PMCID:PMC10260401

• Publication

  released

  Lineage-specific differences and regulatory networks governing human chondrocyte development

  Daniel Richard, Steven Pregizer, Divya Venkatasubramanian, et al.

  Elife. 2023-03-15;15:12:e79925

  • doi:10.7554/eLife.79925
  • PMID:36920035
  • PMCID:PMC10069868