Search – Common Metabolic Diseases Genome Atlas

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Publication
released
An encyclopedia of human enhancer-gene regulatory interactions
Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, et al.
Nature. 2026-07-15;
- PMID:42457959
- doi:10.1038/s41586-026-10781-4
Publication
released
Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition
Mohammadjavad Kahlani, Larry Mesner, Vedavathi Madhu, et al.
bioRxiv. 2026-02-16;(Preprint)
Publication
released
GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density
Mitchell Conery, James A. Pippin, Yadav Wagley, et al.
Genome Biology. 2025-10-03;26(1):331.
Publication
released
Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits
Kevin W Currin, Hannah J Perrin, Gautam K Pandey, et al.
Genome Res. 2025-05-20;
- doi:10.1101/gr.279741.124
- PMID:40393811
Publication
released
Response splicing QTLs in primary human chondrocytes identifies putative osteoarthritis risk genes
Seyoun Byun, Philip Coryell, Nicole Kramer, et al.
bioRxiv. 2024-11-12;
- doi:10.1101/2024.11.11.622754
Publication
released
Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2
Sheridan H Littleton, Khanh B Trang, Christina M Volpe, et al.
Cell Genomics. 2024-05-08;
Data summary: Hi-C, RNA-seq, ATAC-seq, single-nucleus RNA-seq, and single-nucleus ATAC-seq data have been…
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241592
Data summary: Raw and processed Hi-C data GEO: GSE241592
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241050
Data summary: Raw and processed RNA-seq data GEO: GSE241050
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241591
Data summary: Raw and processed ATAC-seq data GEO: GSE241591
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241594
Data summary: Raw and processed single-nucleus RNA-seq data GEO: GSE241594
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241593
Data summary: Raw and processed single-nucleus ATAC-seq data GEO: GSE241593;
Publication
released
Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk
Nicole E Kramer, Philip Coryell, Susan D'Costa, et al.
bioRvix. 2024-05-05;
- doi:10.1101/2024.05.05.592567
Publication
released
Multimodal cell atlas of the ageing human skeletal muscle
Yiwei Lai, Ignacio Ramírez-Pardo, Joan Isern, et al.
Nature. 2024-04-22;
- PMID:38649488
- doi:10.1038/s41586-024-07348-6
Data summary: All raw data have been deposited to CNGB Nucleotide Sequence Archive (CNP0004394, CNP0004395,…
URL: https://db.cngb.org/cdcp/hlma/
Data summary: All processed data are available at the Human Muscle Ageing Cell Atlas database.
URL: https://github.com/MGI-tech-bioinformatics/DNBelab_C_Series_HT_scRNA-analysis-software
Data summary: All data were analysed using standard programs and packages, as described in the Methods. Custom…
URL: https://github.com/123anjuan/HMA
Data summary: Analysis of the generated data82.
Publication
released
An integrated map of cell type-specific gene expression in pancreatic islets
Ruth M Elgamal, Parul Kudtarkar, Rebecca L Melton, et al.
Diabetes. 2023-15-08;(db230130)
- PMID:37582230
- doi:10.2337/db23-0130
Publication
released
Population-scale skeletal muscle single-nucleus multi-omic profiling reveals extensive context specific genetic regulation
Arushi Varshney Arushi Varshney, Nandini Manickam, Peter Orchard, et al.
bioRxiv. 2023-12-15;
URL: https://www.biorxiv.org/content/10.1101/2023.12.15.571696v2
Publication
released
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes
Fan Zhang, Anna Helena Jonsson, Aparna Nathan, et al.
Nature. 2023-11-08;623(7987):616-624.
URL: https://doi.org/10.7303/syn52297840
Data summary: CITE-seq single-cell expression matrices and sequencing and bulk expression matrices are available…
URL: https://arkportal.synapse.org/Explore/Datasets/DetailsPage?id=syn52297840
Data summary: Associated genotype and clinical data are available through the Arthritis and Autoimmune and…
URL: https://immunogenomics.io/ampra2/
Data summary: A cell browser website is available to visualize our data and results.
Data summary: AMP Phase 1 single-cell data from ref. 8 are available on Immport (SDY998). PEAC clinical trial…
URL: https://github.com/Immunogenomics/RA_Atlas_CITEseq/
Data summary: The source code for the analyses is available at GitHub
URL: https://zenodo.org/record/8118599
Data summary: The source code for the analyses is available at zenodo
Publication
released
Genome-wide analysis of the interplay between chromatin-associated RNA and 3D genome organization in human cells
Riccardo Calandrelli, Xingzhao We, John Lalith Charles Richard, et al.
Nat Commun. 2023-10-16;14(1):6519.
Available supplemental data: website
URL: https://data.4dnucleome.org
Data summary: All high-throughput data supporting the current study have been deposited on the 4D Nucleome Data…
Available supplemental data: website
URL: https://github.com/Zhong-Lab-UCSD/RNA3Dgenome-code-repository
Data summary: The codes used for the analysis have been deposited and made publicly available on GitHub at…
Publication
released
A comparative atlas of single-cell chromatin accessibility in the human brain
Yang Eric Li, Sebastian Preissl, Michael Miller, et al.
Science. 2023-10-13;382(6667)
Publication
released
Plasma proteomic associations with genetics and health in the UK Biobank
Benjamin B Sun, Joshua Chiou, Matthew Traylor, et al.
Nature. 2023-10-04;622(7982):329-338.
URL: http://ukb-ppp.gwas.eu
Data summary: Proteo-genomic results and summary association data are available through an interactive portal.
URL: https://www.ukbiobank.ac.uk/enable-your-research
Data summary: Underlying NPX measures are available through the UK Biobank Research Analysis Portal.
URL: https://biobank.ndph.ox.ac.uk/showcase/label.cgi?id=1839
Data summary: UKB has catalogued the dataset in Category 1839, under ‘Field 30900’, described in greater detail…
Publication
released
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions
Renhe Luo, Jielin Yan, Jin Woo Oh, et al.
at Genet. 2023-07-24;55(8):1336-1346.
- doi:10.1038/s41588-023-01450-7
- PMID:37488417
Available supplemental data: website
Data summary: The parental HUES8 hESC line was obtained from Harvard University under a material transfer…
Publication
released
An atlas of healthy and injured cell states and niches in the human kidney
Blue B. Lake, Rajasree Menon, Seth Winfree, et al.
Nature. 2023-07-19;619(7970):585-594.
URL: https://www.nature.com/articles/s41586-023-05769-3
Publication
released
Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes
Kristina M. Garske, Asha Kar, Caroline Comenho, et al.
Nat Commun. 2023-07-14;14(1):4214.
Publication
released
Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture
Linda Kachuri, Angel C. Y. Mak, Donglei Hu, et al.
Nat Genet. 2023-05-25;55(6):952-963.
Publication
released
Lineage-specific differences and regulatory networks governing human chondrocyte development
Daniel Richard, Steven Pregizer, Divya Venkatasubramanian, et al.
Elife. 2023-03-15;15:12:e79925
Publication
released
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
Katia K. Mattis, Nicole A. J. Krentz, Christoph Metzendorf, et al.
Diabetologia. 2023-01-12;
- doi:10.1007/s00125-022-05856-6
- PMID:36633628

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Showing 20 of 269 results