Search – Common Metabolic Diseases Genome Atlas

Showing 12 of 12 results

Publication
released
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
Hongbo Liu, Tomohito Doke, Dong Guo, et al.
Nature Genetics. 2022-06-16;54:950–962.
- PMID:35710981
- doi:10.1038/s41588-022-01097-w
Available supplemental data: website
URL: https://github.com/hbliu/Kidney_Epi_Pri
Data summary: Customized code used in the present study is available at github
Available supplemental data: website
URL: https://doi.org/10.5281/zenodo.6392494
Data summary: Zenodo
Publication
released
Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity
Steven Gazal, Omer Weissbrod, Farhad Hormozdiari, et al.
Nature Genetics. 2022-06-06;(2022)
- doi:10.1101/2021.08.02.21261488
URL: https://doi.org/10.5281/zenodo.6354007
Data summary: The list of 19,995 genes, summary statistics of the 63 independent traits, training and validation…
Data summary: Links for all data sets used to create S2G strategies are provided in Supplementary Table 26.
URL: http://www.ukbiobank.ac.uk/
Data summary: Access to the UK Biobank resource is available via application
URL: https://www.ebi.ac.uk/gwas/api/search/downloads/full
Data summary: The GWAS Catalog is available
URL: https://raw.githubusercontent.com/opentargets/genetics-gold-standards/master/gold_standards/processed/gwas_gold_standards.191108.tsv
Data summary: Open Targets SNP–gene pairs are available
URL: https://www.dropbox.com/s/kz2c49rpm2yanf5/all_byCS_rev1.txt?dl=0
Data summary: SNP–gene pairs from ref48 are available
URL: https://alkesgroup.broadinstitute.org/cS2G/code
Data summary: The code to estimate precision and recall of S2G strategies and the code to create combined S2G…
URL: https://doi.org/10.5281/zenodo.6415925
Data summary: The code to estimate precision and recall of S2G strategies and the code to create combined S2G…
Publication
released
Landscape of stimulation-responsive chromatin across diverse human immune cells
Diego Calderon, Michelle L. T. Nguyen, Anja Mezger, et al.
Nature Genetics. 2019-9-30;51:1494–1505.
Publication
released
Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases
Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, et al.
Nature Genetics. 2019-9-23;51:1486–1493.
Publication
released
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, et al.
Nature Genetics. 2019-11-01;51:1588–1595.
- doi:10.1038/s41588-019-0524-6
- PMID:31676868
Publication
released
A compendium of promoter-centered long-range chromatin interactions in the human genome
Inkyung Jung, Anthony Schmitt, Yarui Diao, et al.
Nature Genetics. 2019-09-09;51:1442–1449.
- doi:10.1038/s41588-019-0494-8
- PMID:31501517
URL: https://www.nature.com/articles/s41588-019-0494-8
Publication
released
Human Pancreatic Islet Three-dimensional Chromatin Architecture Provides Insights into The Genetics of Type 2 Diabetes
Irene Miguel-Escalada, Silvia Bonàs-Guarch, Inês Cebola, et al.
Nature Genetics. 2019-06-28;51:1137-1148.
- doi:10.1038/s41588-019-0457-0
- PMID:31253982
URL: https://www.nature.com/articles/s41588-019-0457-0
Publication
released
Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration
Rinki Ratnapriya, Olukayode A. Sosina, Margaret R. Starostik, et al.
Nature Genetics. 2019-02-11;51:606–610.
- doi:10.1038/s41588-019-0351-9
- PMID:30742112
Publication
released
Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs
Monique G P van der Wijst, Harm Brugge, Dylan H de Vries, et al.
Nature Genetics. 2018-4-2;50:493–497.
Publication
released
An Atlas of Genetic Influences on Osteoporosis in Humans and Mice
John A. Morris, John P. Kemp, Scott E. Youlten, et al.
Nature Genetics. 2018-12-31;51(2):258-266.
URL: https://www.nature.com/articles/s41588-018-0302-x
Publication
released
Pancreatic Islet Enhancer Clusters Enriched In Type 2 Diabetes Risk–associated Variants
Lorenzo Pasquali, Kyle J. Gaulton, Santiago A. Rodríguez-Seguí, et al.
Nature Genetics. 2014-02;46(2):136-143.
- doi:10.1038/ng.2870
- PMID:24413736
Publication
released
A map of open chromatin in human pancreatic islets
Kyle J Gaulton, Takao Nammo, Lorenzo Pasquali, et al.
Nature Genetics. 2010-01-01;42(3):255–259.
- PMID:20118932
- doi:10.1038/ng.530

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