Showing 20 of 20 results

• Publication

  released

  A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk

  Antje K Rottner, Yingying Ye, Elena Navarro-Guerrero, et al.

  Nat Genet. 2022-12-21;55(1):54-65.

  • doi:10.1038/s41588-022-01261-2
  • PMID:36543916
  • PMCID:PMC9839450

  URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839450/

  Available supplemental data: website

  File format: text

  URL: https://hugeamp.org:8000/research.html?pageid=beta_cell_249

  Data summary: Pancreatic beta cell function and type 2 diabetes predicted effector genes (Rottner AK et al., 2023)

• Publication

  released

  Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells

  Kousuke Mouri, Michael H. Guo, Carl G. de Boer, et al.

  Nat Genet. 2022-05-01;54(5):603-612.

  • doi:10.1038/s41588-022-01056-5
  • PMID:35513721

• Publication

  released

  A map of transcriptional heterogeneity and regulatory variation in human microglia

  Adam M. H. Young, Natsuhiko Kumasaka, Fiona Calvert, et al.

  Nat Genet. 2021-06-03;53(6):861-868.

  • doi:10.1038/s41588-021-00875-2
  • PMID:34083789
  • PMCID:PMC7610960

• Publication

  released

  Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk

  Joshua Chiou, Chun Zeng, Zhang Cheng, et al.

  Nat Genet. 2021-04-01;53(4):455-466.

  • doi:10.1038/s41588-021-00823-0
  • PMID:33795864

• Publication

  released

  Liquid chromatin Hi-C characterizes compartment-dependent chromatin interaction dynamics

  Houda Belaghzal, Tyler Borrman, Andrew D Stephens, et al.

  Nat Genet. 2021-02-11;53(3):367-378.

  • doi:10.1038/s41588-021-00784-4
  • PMID:33574602
  • PMCID:PMC7946813

  Data summary: All sequencing data have been submitted to a public data repository (GEO; accession number…See more

• Publication

  released

  Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases

  M Ryan Corces, Anna Shcherbina, Soumya Kundu, et al.

  Nat Genet. 2020 Oct 26;52(11):1158-1168.

  • doi:10.1038/s41588-020-00721-x
  • PMID:33106633
  • PMCID:PMC7606627

• Publication

  released

  Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits

  Chelsea K Raulerson, Arthur Ko, John C Kidd, et al.

  AJHG. 2019-10-03;105(4):773-787.

  • doi:10.1016/j.ajhg.2019.09.001
  • PMID:31564431
  • PMCID:PMC6817527

• Publication

  released

  Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells

  Yanxiao Zhang, Ting Li, Sebastian Preissl, et al.

  Nat Genet. 2019-08-19;51(9):1380-1388.

  • doi:10.1038/s41588-019-0479-7
  • PMID:31427791
  • PMCID:PMC6722002

  Available supplemental data: website

  Data summary: All sequencing datasets have been deposited on GEO with the accession number GSE116862.

• Publication

  released

  Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver

  Minal C ̧alıs ̧kan, Elisabetta Manduchi, H. Shanker Rao, et al.

  AJHG. 2019-07-03;105(1):89-107.

  • doi:10.1016/j.ajhg.2019.05.010
  • PMID:31204013

  URL: https://www.sciencedirect.com/science/article/pii/S0002929719301971

• Publication

  released

  Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

  Anubha Mahajan, Daniel Taliun, Matthias Thurner, et al.

  Nat Genet. 2018-10-08;50(11):1505-1513.

  • doi:10.1038/s41588-018-0241-6
  • PMID:30297969
  • PMCID:PMC6287706

• Publication

  released

  An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome

  Christopher E. Gillies, Rosemary Putler, Rajasree Menon, et al.

  AJHG. 2018-08-02;103(2):232-244.

  • doi:10.1016/j.ajhg.2018.07.004
  • PMID:30057032

  URL: https://umich.app.box.com/s/6jrvgmdh0ppwqvgriuvijiau0xcb4ohm

• Publication

  released

  Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

  Soren K Thomsen, Anne Raimondo, Benoit Hastoy, et al.

  Nat Genet. 2018-07-27;50(8):1122-1131.

  • doi:10.1038/s41588-018-0173-1
  • PMID:30054598
  • PMCID:PMC6237273

• Publication

  released

  Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

  Kerrin S Small, Marijana Todorčević, Mete Civelek, et al.

  Nat Genet. 2018-04-09;50(4):572-580.

  • doi:10.1038/s41588-018-0088-x
  • PMID:29632379
  • PMCID:PMC5935235

• Publication

  released

  Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response

  Kaur Alasoo, Julia Rodrigues, Subhankar Mukhopadhyay, et al.

  Nat Genet. 2018-01-29;50(3):424-431.

  • doi:10.1038/s41588-018-0046-7
  • PMID:29379200
  • PMCID:PMC6548559

• Publication

  released

  Molecular and functional variation in iPSC-derived sensory neurons

  Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, et al.

  Nat Genet. 2017-12-11;50(1):54-61.

  • doi:10.1038/s41588-017-0005-8
  • PMID:29229984
  • PMCID:PMC5742539

• Publication

  released

  Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease

  Yi-An Ko, Huiguang Yi, Chengxiang Qiu, et al.

  AJHG. 2017-06-01;100(6):940-953.

  • doi:10.1016/j.ajhg.2017.05.004
  • PMID:28575649

  URL: https://www.sciencedirect.com/science/article/pii/S000292971730191X?via%3Dihub

• Publication

  released

  Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

  Mete Civelek, Ying Wu, Calvin Pan, et al.

  AJHG. 2017-03-02;100(3):428–443.

  • doi:10.1016/j.ajhg.2017.01.027
  • PMID:28257690
  • PMCID:PMC5339333

  Available supplemental data: website

  URL: http://dx.doi.org/10.1016/j.ajhg.2017.01.027

  Data summary: Supplemental Data include 8 figures and 14 tables and can be found with this article.

• Publication

  released

  Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

  Kaixin Zhou, Sook Wah Yee, Eric L Seiser, et al.

  Nat Genet. 2016-08-08;48(9):1055-1059.

  • doi:10.1038/ng.3632
  • PMID:27500523
  • PMCID:PMC5007158

• Publication

  released

  Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins

  Alfonso Buil, Andrew Anand Brown, Tuuli Lappalainen, et al.

  Nat Genet. 2014-12-01;47(1):88-91.

  • doi:10.1038/ng.3162
  • PMID:25436857
  • PMCID:PMC4643454

• Publication

  released

  Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s Disease

  Samuel Morabito, Emily Miyoshi, Neethu Michael, et al.

  Nat Genet. 2021-07-08;53(8):1143-1155.

  • doi:10.1038/s41588-021-00894-z
  • PMID:34239132
  • PMCID:PMC8766217

  Available supplemental data: website

  File format: other format

  URL: https://www.synapse.org/#!Synapse:syn22079621/

  Data summary: All the multi-omics raw and processed data are available here

  Available supplemental data: website

  File format: other format

  URL: http://swaruplab.bio.uci.edu/singlenucleiAD/

  Data summary: The data can be accessed through online web app

  Available supplemental data: website

  File format: other format

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174367

  Data summary: Raw sequencing data have been deposited into the National Center for Biotechnology Information…See more