Search – Common Metabolic Diseases Genome Atlas

Showing 22 of 22 results

Publication
released
Genome-wide analysis of the interplay between chromatin-associated RNA and 3D genome organization in human cells
Riccardo Calandrelli, Xingzhao We, John Lalith Charles Richard, et al.
Nat Commun. 2023-10-16;14(1):6519.
Available supplemental data: website
URL: https://data.4dnucleome.org
Data summary: All high-throughput data supporting the current study have been deposited on the 4D Nucleome Data…
Available supplemental data: website
URL: https://github.com/Zhong-Lab-UCSD/RNA3Dgenome-code-repository
Data summary: The codes used for the analysis have been deposited and made publicly available on GitHub at…
Publication
released
A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk
Antje K Rottner, Yingying Ye, Elena Navarro-Guerrero, et al.
Nat Genet. 2022-12-21;55(1):54-65.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839450/
Available supplemental data: website
File format: text
URL: https://hugeamp.org:8000/research.html?pageid=beta_cell_249
Data summary: Pancreatic beta cell function and type 2 diabetes predicted effector genes (Rottner AK et al., 2023)
Publication
released
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells
Kousuke Mouri, Michael H. Guo, Carl G. de Boer, et al.
Nat Genet. 2022-05-01;54(5):603-612.
- doi:10.1038/s41588-022-01056-5
- PMID:35513721
Publication
released
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, et al.
Nat Commun. 2021-11-19;12(1):6749.
Publication
released
Systematic evaluation of chromosome conformation capture assays
Betul Akgol Oksuz, Liyan Yang, Sameer Abraham, et al.
Nat Methods. 2021-09-03;18(9):1046-1055.
Data summary: Data are available at GEO under accession number GSE163666. Supplementary Table 1 lists datasets…
Available supplemental data: website
URL: https://github.com/dekkerlab/matrix_paper
Data summary: Scripts and notebooks used in this paper can be accessed at…
Publication
released
Joint disease-specificity at the regulatory base-pair level
Pushpanathan Muthuirulan, Dewei Zhao, Mariel Young, et al.
Nat Commun. 2021-07-06;12(1):4161.
Publication
released
A map of transcriptional heterogeneity and regulatory variation in human microglia
Adam M. H. Young, Natsuhiko Kumasaka, Fiona Calvert, et al.
Nat Genet. 2021-06-03;53(6):861-868.
Publication
released
Liquid chromatin Hi-C characterizes compartment-dependent chromatin interaction dynamics
Houda Belaghzal, Tyler Borrman, Andrew D Stephens, et al.
Nat Genet. 2021-02-11;53(3):367-378.
Data summary: All sequencing data have been submitted to a public data repository (GEO; accession number…
Publication
released
Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons
Mads E. Hauberg, Jordi Creus-Muncunill, Jaroslav Bendl, et al.
Nat Commun. 2020-11-04;11(1):5581.
Publication
released
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
Ana Viñuela, Arushi Varshney, Martijn van de Bunt, et al.
Nat Commun. 2020-09-30;11(1):4912.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7528108/
Publication
released
Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information
Sebastian Guelfi, Karishma D’Sa, Juan A. Botía, et al.
Nat Commun. 2020-02-25;11(1):1041.
Publication
released
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells
Yanxiao Zhang, Ting Li, Sebastian Preissl, et al.
Nat Genet. 2019-08-19;51(9):1380-1388.
Available supplemental data: website
Data summary: All sequencing datasets have been deposited on GEO with the accession number GSE116862.
Publication
released
Functional testing of thousands of osteoarthritis-associated variants for regulatory activity
Jason C Klein, Aidan Keith, Sarah J Rice, et al.
Nat Commun. 2019-06-04;10(1):2434.
Publication
released
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Anubha Mahajan, Daniel Taliun, Matthias Thurner, et al.
Nat Genet. 2018-10-08;50(11):1505-1513.
Publication
released
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells
Soren K Thomsen, Anne Raimondo, Benoit Hastoy, et al.
Nat Genet. 2018-07-27;50(8):1122-1131.
Publication
released
ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration
Jie Wang, Cristina Zibetti, Peng Shang, et al.
Nat Commun. 2018-04-10;9(1):1364.
Publication
released
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition
Kerrin S Small, Marijana Todorčević, Mete Civelek, et al.
Nat Genet. 2018-04-09;50(4):572-580.
Publication
released
Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response
Kaur Alasoo, Julia Rodrigues, Subhankar Mukhopadhyay, et al.
Nat Genet. 2018-01-29;50(3):424-431.
Publication
released
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, et al.
Nat Commun. 2018-01-22;9(1):321.
Publication
released
Molecular and functional variation in iPSC-derived sensory neurons
Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, et al.
Nat Genet. 2017-12-11;50(1):54-61.
Publication
released
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
Kaixin Zhou, Sook Wah Yee, Eric L Seiser, et al.
Nat Genet. 2016-08-08;48(9):1055-1059.
Publication
released
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
Alfonso Buil, Andrew Anand Brown, Tuuli Lappalainen, et al.
Nat Genet. 2014-12-01;47(1):88-91.