Search – Common Metabolic Diseases Genome Atlas

Showing 17 of 17 results

Publication
released
A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk
Antje K Rottner, Yingying Ye, Elena Navarro-Guerrero, et al.
Nat Genet. 2022-12-21;55(1):54-65.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839450/
Available supplemental data: website
File format: text
URL: https://hugeamp.org:8000/research.html?pageid=beta_cell_249
Data summary: Pancreatic beta cell function and type 2 diabetes predicted effector genes (Rottner AK et al., 2023)
Publication
released
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells
Kousuke Mouri, Michael H. Guo, Carl G. de Boer, et al.
Nat Genet. 2022-05-01;54(5):603-612.
- doi:10.1038/s41588-022-01056-5
- PMID:35513721
Publication
released
Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci
Hannah J Perrin, Kevin W Currin, Swarooparani Vadlamudi, et al.
PLoS Genet. 2021-10-26;17(10):e1009865.
Publication
released
Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes
Anthony Aylward, Mei-Lin Okino, Paola Benaglio, et al.
PLoS Genet. 2021-05-13;17(5):e1009531.
Publication
released
Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk
Joshua Chiou, Chun Zeng, Zhang Cheng, et al.
Nat Genet. 2021-04-01;53(4):455-466.
- doi:10.1038/s41588-021-00823-0
- PMID:33795864
Publication
released
Liquid chromatin Hi-C characterizes compartment-dependent chromatin interaction dynamics
Houda Belaghzal, Tyler Borrman, Andrew D Stephens, et al.
Nat Genet. 2021-02-11;53(3):367-378.
Data summary: All sequencing data have been submitted to a public data repository (GEO; accession number…
Publication
released
Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases
M Ryan Corces, Anna Shcherbina, Soumya Kundu, et al.
Nat Genet. 2020 Oct 26;52(11):1158-1168.
Publication
released
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells
Yanxiao Zhang, Ting Li, Sebastian Preissl, et al.
Nat Genet. 2019-08-19;51(9):1380-1388.
Available supplemental data: website
Data summary: All sequencing datasets have been deposited on GEO with the accession number GSE116862.
Publication
released
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Anubha Mahajan, Daniel Taliun, Matthias Thurner, et al.
Nat Genet. 2018-10-08;50(11):1505-1513.
Publication
released
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells
Soren K Thomsen, Anne Raimondo, Benoit Hastoy, et al.
Nat Genet. 2018-07-27;50(8):1122-1131.
Publication
released
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition
Kerrin S Small, Marijana Todorčević, Mete Civelek, et al.
Nat Genet. 2018-04-09;50(4):572-580.
Publication
released
Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey
Cassandra N Spracklen, Jinxiu Shi, Swarooparani Vadlamudi, et al.
PLoS Genet. 2018-04-05;14(4):e1007275.
Publication
released
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
Kaixin Zhou, Sook Wah Yee, Eric L Seiser, et al.
Nat Genet. 2016-08-08;48(9):1055-1059.
Publication
released
Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci
Olga Sazonova, Yuqi Zhao, Sylvia Nürnberg, et al.
PLoS Genet. 2015-05-28;11(5):e1005202.
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE61369
Publication
released
Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue
Federico Innocenti, Gregory M Cooper, Ian B Stanaway, et al.
PLoS Genet. 2011-05-26;7(5):e1002078.
Publication
released
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors
Martijn van de Bunt, Jocelyn E Manning Fox, Xiaoqing Dai, et al.
PLoS Genet. . 2015-12-01;11(12):e1005694.
Publication
released
Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s Disease
Samuel Morabito, Emily Miyoshi, Neethu Michael, et al.
Nat Genet. 2021-07-08;53(8):1143-1155.
Available supplemental data: website
File format: other format
URL: https://www.synapse.org/#!Synapse:syn22079621/
Data summary: All the multi-omics raw and processed data are available here
Available supplemental data: website
File format: other format
URL: http://swaruplab.bio.uci.edu/singlenucleiAD/
Data summary: The data can be accessed through online web app
Available supplemental data: website
File format: other format
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174367
Data summary: Raw sequencing data have been deposited into the National Center for Biotechnology Information…