Showing 13 of 13 results

• Publication

  released

  Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity

  Steven Gazal, Omer Weissbrod, Farhad Hormozdiari, et al.

  Nature Genetics. 2022-06-06;(2022)

  • doi:10.1101/2021.08.02.21261488

  URL: https://doi.org/10.5281/zenodo.6354007

  Data summary: The list of 19,995 genes, summary statistics of the 63 independent traits, training and validation…See more

  Data summary: Links for all data sets used to create S2G strategies are provided in Supplementary Table 26.

  URL: http://www.ukbiobank.ac.uk/

  Data summary: Access to the UK Biobank resource is available via application

  URL: https://www.ebi.ac.uk/gwas/api/search/downloads/full

  Data summary: The GWAS Catalog is available

  URL: https://raw.githubusercontent.com/opentargets/genetics-gold-standards/master/gold_standards/processed/gwas_gold_standards.191108.tsv

  Data summary: Open Targets SNP–gene pairs are available

  URL: https://www.dropbox.com/s/kz2c49rpm2yanf5/all_byCS_rev1.txt?dl=0

  Data summary: SNP–gene pairs from ref48 are available

  URL: https://alkesgroup.broadinstitute.org/cS2G/code

  Data summary: The code to estimate precision and recall of S2G strategies and the code to create combined S2G…See more

  URL: https://doi.org/10.5281/zenodo.6415925

  Data summary: The code to estimate precision and recall of S2G strategies and the code to create combined S2G…See more

• Publication

  released

  Landscape of stimulation-responsive chromatin across diverse human immune cells

  Diego Calderon, Michelle L. T. Nguyen, Anja Mezger, et al.

  Nature Genetics. 2019-9-30;51:1494–1505.

  • doi:10.1038/s41588-019-0505-9
  • PMID:31570894
  • PMCID:PMC6858557

• Publication

  released

  Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases

  Blagoje Soskic, Eddie Cano-Gamez, Deborah J. Smyth, et al.

  Nature Genetics. 2019-9-23;51:1486–1493.

  • doi:10.1038/s41588-019-0493-9
  • PMCID:PMC6872452
  • PMID:31548716

• Publication

  released

  The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

  Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, et al.

  Nature Genetics. 2019-11-01;51:1588–1595.

  • doi:10.1038/s41588-019-0524-6
  • PMID:31676868

• Publication

  released

  A compendium of promoter-centered long-range chromatin interactions in the human genome

  Inkyung Jung, Anthony Schmitt, Yarui Diao, et al.

  Nature Genetics. 2019-09-09;51:1442–1449.

  • doi:10.1038/s41588-019-0494-8
  • PMID:31501517

  URL: https://www.nature.com/articles/s41588-019-0494-8

• Publication

  released

  Human Pancreatic Islet Three-dimensional Chromatin Architecture Provides Insights into The Genetics of Type 2 Diabetes

  Irene Miguel-Escalada, Silvia Bonàs-Guarch, Inês Cebola, et al.

  Nature Genetics. 2019-06-28;51:1137-1148.

  • doi:10.1038/s41588-019-0457-0
  • PMID:31253982

  URL: https://www.nature.com/articles/s41588-019-0457-0

• Publication

  released

  Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration

  Rinki Ratnapriya, Olukayode A. Sosina, Margaret R. Starostik, et al.

  Nature Genetics. 2019-02-11;51:606–610.

  • doi:10.1038/s41588-019-0351-9
  • PMID:30742112

• Publication

  released

  Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs

  Monique G P van der Wijst, Harm Brugge, Dylan H de Vries, et al.

  Nature Genetics. 2018-4-2;50:493–497.

  • doi:10.1038/s41588-018-0089-9
  • PMCID:PMC5905669
  • PMID:29610479

• Publication

  released

  An Atlas of Genetic Influences on Osteoporosis in Humans and Mice

  John A. Morris, John P. Kemp, Scott E. Youlten, et al.

  Nature Genetics. 2018-12-31;51(2):258-266.

  • doi:10.1038/s41588-018-0302-x
  • PMID:30598549
  • PMCID:PMC6358485

  URL: https://www.nature.com/articles/s41588-018-0302-x

• Publication

  released

  Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

  ndrew E. Jaffe, Richard E. Straub, Joo Heon Shin, et al.

  Nat Neurosci. 2018-07-26;21(8):1117-1125.

  • doi:10.1038/s41593-018-0197-y
  • PMID:30050107
  • PMCID:PMC6438700

• Publication

  released

  An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

  Bernard Ng, Charles C White, Hans-Ulrich Klein, et al.

  Nat Neurosci. 2017-09-04;20(10):1418-1426.

  • doi:10.1038/nn.4632
  • PMID:28869584
  • PMCID:PMC5785926

• Publication

  released

  Pancreatic Islet Enhancer Clusters Enriched In Type 2 Diabetes Risk–associated Variants

  Lorenzo Pasquali, Kyle J. Gaulton, Santiago A. Rodríguez-Seguí, et al.

  Nature Genetics. 2014-02;46(2):136-143.

  • doi:10.1038/ng.2870
  • PMID:24413736

• Publication

  released

  A map of open chromatin in human pancreatic islets

  Kyle J Gaulton, Takao Nammo, Lorenzo Pasquali, et al.

  Nature Genetics. 2010-01-01;42(3):255–259.

  • PMID:20118932
  • doi:10.1038/ng.530