Showing 21 of 21 results

• Publication

  released

  A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk

  Antje K Rottner, Yingying Ye, Elena Navarro-Guerrero, et al.

  Nat Genet. 2022-12-21;55(1):54-65.

  • doi:10.1038/s41588-022-01261-2
  • PMID:36543916
  • PMCID:PMC9839450

  URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839450/

  Available supplemental data: website

  File format: text

  URL: https://hugeamp.org:8000/research.html?pageid=beta_cell_249

  Data summary: Pancreatic beta cell function and type 2 diabetes predicted effector genes (Rottner AK et al., 2023)

• Publication

  released

  Single-cell gene expression and chromatin accessibility profiling of human pancreatic islets at basal and stimulatory conditions nominates mechanisms of type 1 diabetes genetic risk

  Ricardo D’Oliveira Albanus, Xuming Tang, Henry J. Taylor, et al.

  bioRxiv. 2022-11-14;

  • doi:10.1101/2022.11.12.516291

• Publication

  released

  Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells

  Kousuke Mouri, Michael H. Guo, Carl G. de Boer, et al.

  Nat Genet. 2022-05-01;54(5):603-612.

  • doi:10.1038/s41588-022-01056-5
  • PMID:35513721

• Publication

  released

  Cryomilling Tethered Chromatin Conformation Capture reveal new insights into inter-chromosomal interactions

  Jiang Xu, Sanjeev Kumar, Nan Hua, et al.

  bioRxiv. 2022-02-12;

  • doi:10.1101/2022.02.03.478915

• Publication

  released

  A map of transcriptional heterogeneity and regulatory variation in human microglia

  Adam M. H. Young, Natsuhiko Kumasaka, Fiona Calvert, et al.

  Nat Genet. 2021-06-03;53(6):861-868.

  • doi:10.1038/s41588-021-00875-2
  • PMID:34083789
  • PMCID:PMC7610960

• Publication

  released

  Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk

  Joshua Chiou, Chun Zeng, Zhang Cheng, et al.

  Nat Genet. 2021-04-01;53(4):455-466.

  • doi:10.1038/s41588-021-00823-0
  • PMID:33795864

• Publication

  released

  Liquid chromatin Hi-C characterizes compartment-dependent chromatin interaction dynamics

  Houda Belaghzal, Tyler Borrman, Andrew D Stephens, et al.

  Nat Genet. 2021-02-11;53(3):367-378.

  • doi:10.1038/s41588-021-00784-4
  • PMID:33574602
  • PMCID:PMC7946813

  Data summary: All sequencing data have been submitted to a public data repository (GEO; accession number…See more

• Publication

  released

  Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

  C.C. Robertson, J.R.J. Inshaw, S. Onengut-Gumuscu, et al.

  bioRxiv. 2020-06-20;

  • doi:10.1101/2020.06.19.158071

• Publication

  released

  Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases

  M Ryan Corces, Anna Shcherbina, Soumya Kundu, et al.

  Nat Genet. 2020 Oct 26;52(11):1158-1168.

  • doi:10.1038/s41588-020-00721-x
  • PMID:33106633
  • PMCID:PMC7606627

• Publication

  released

  Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells

  Yanxiao Zhang, Ting Li, Sebastian Preissl, et al.

  Nat Genet. 2019-08-19;51(9):1380-1388.

  • doi:10.1038/s41588-019-0479-7
  • PMID:31427791
  • PMCID:PMC6722002

  Available supplemental data: website

  Data summary: All sequencing datasets have been deposited on GEO with the accession number GSE116862.

• Publication

  released

  Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

  Anubha Mahajan, Daniel Taliun, Matthias Thurner, et al.

  Nat Genet. 2018-10-08;50(11):1505-1513.

  • doi:10.1038/s41588-018-0241-6
  • PMID:30297969
  • PMCID:PMC6287706

• Publication

  released

  Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

  Soren K Thomsen, Anne Raimondo, Benoit Hastoy, et al.

  Nat Genet. 2018-07-27;50(8):1122-1131.

  • doi:10.1038/s41588-018-0173-1
  • PMID:30054598
  • PMCID:PMC6237273

• Publication

  released

  Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

  Kerrin S Small, Marijana Todorčević, Mete Civelek, et al.

  Nat Genet. 2018-04-09;50(4):572-580.

  • doi:10.1038/s41588-018-0088-x
  • PMID:29632379
  • PMCID:PMC5935235

• Publication

  released

  Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response

  Kaur Alasoo, Julia Rodrigues, Subhankar Mukhopadhyay, et al.

  Nat Genet. 2018-01-29;50(3):424-431.

  • doi:10.1038/s41588-018-0046-7
  • PMID:29379200
  • PMCID:PMC6548559

• Publication

  released

  Molecular and functional variation in iPSC-derived sensory neurons

  Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, et al.

  Nat Genet. 2017-12-11;50(1):54-61.

  • doi:10.1038/s41588-017-0005-8
  • PMID:29229984
  • PMCID:PMC5742539

• Publication

  released

  Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

  Kaixin Zhou, Sook Wah Yee, Eric L Seiser, et al.

  Nat Genet. 2016-08-08;48(9):1055-1059.

  • doi:10.1038/ng.3632
  • PMID:27500523
  • PMCID:PMC5007158

• Publication

  released

  Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins

  Alfonso Buil, Andrew Anand Brown, Tuuli Lappalainen, et al.

  Nat Genet. 2014-12-01;47(1):88-91.

  • doi:10.1038/ng.3162
  • PMID:25436857
  • PMCID:PMC4643454

• Publication

  released

  Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s Disease

  Samuel Morabito, Emily Miyoshi, Neethu Michael, et al.

  Nat Genet. 2021-07-08;53(8):1143-1155.

  • doi:10.1038/s41588-021-00894-z
  • PMID:34239132
  • PMCID:PMC8766217

  Available supplemental data: website

  File format: other format

  URL: https://www.synapse.org/#!Synapse:syn22079621/

  Data summary: All the multi-omics raw and processed data are available here

  Available supplemental data: website

  File format: other format

  URL: http://swaruplab.bio.uci.edu/singlenucleiAD/

  Data summary: The data can be accessed through online web app

  Available supplemental data: website

  File format: other format

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174367

  Data summary: Raw sequencing data have been deposited into the National Center for Biotechnology Information…See more

• Publication

  released

  The three-dimensional chromatin structure of the major human pancreatic cell types reveals lineage-specific regulatory architecture of T2D risk

  Chun Su, Long Gao, Catherine L. May, et al.

  bioRxiv.

  • doi:10.1101/2021.11.30.470653

• Publication

  released

  Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex trait variants using single nucleus ATAC-seq

  Paola Benaglio, Jacklyn Newsome, Jee Yun Han, et al.

  bioRxiv.

  • doi:10.1101/2020.12.03.387894

• Publication

  released

  Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

  Xin Sheng, Ziyuan Ma, Junnan Wu, et al.

  bioRxiv.

  • doi:10.1101/2020.11.09.375592