Search – Common Metabolic Diseases Genome Atlas

Showing 17 of 17 results

Publication
released
A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk
Antje K Rottner, Yingying Ye, Elena Navarro-Guerrero, et al.
Nat Genet. 2022-12-21;55(1):54-65.
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839450/
Available supplemental data: website
File format: text
URL: https://hugeamp.org:8000/research.html?pageid=beta_cell_249
Data summary: Pancreatic beta cell function and type 2 diabetes predicted effector genes (Rottner AK et al., 2023)
Publication
released
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells
Kousuke Mouri, Michael H. Guo, Carl G. de Boer, et al.
Nat Genet. 2022-05-01;54(5):603-612.
- doi:10.1038/s41588-022-01056-5
- PMID:35513721
Publication
released
A map of transcriptional heterogeneity and regulatory variation in human microglia
Adam M. H. Young, Natsuhiko Kumasaka, Fiona Calvert, et al.
Nat Genet. 2021-06-03;53(6):861-868.
Publication
released
Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk
Joshua Chiou, Chun Zeng, Zhang Cheng, et al.
Nat Genet. 2021-04-01;53(4):455-466.
- doi:10.1038/s41588-021-00823-0
- PMID:33795864
Publication
released
Liquid chromatin Hi-C characterizes compartment-dependent chromatin interaction dynamics
Houda Belaghzal, Tyler Borrman, Andrew D Stephens, et al.
Nat Genet. 2021-02-11;53(3):367-378.
Data summary: All sequencing data have been submitted to a public data repository (GEO; accession number…
Publication
released
Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases
M Ryan Corces, Anna Shcherbina, Soumya Kundu, et al.
Nat Genet. 2020 Oct 26;52(11):1158-1168.
Publication
released
Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells
Yanxiao Zhang, Ting Li, Sebastian Preissl, et al.
Nat Genet. 2019-08-19;51(9):1380-1388.
Available supplemental data: website
Data summary: All sequencing datasets have been deposited on GEO with the accession number GSE116862.
Publication
released
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Anubha Mahajan, Daniel Taliun, Matthias Thurner, et al.
Nat Genet. 2018-10-08;50(11):1505-1513.
Publication
released
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells
Soren K Thomsen, Anne Raimondo, Benoit Hastoy, et al.
Nat Genet. 2018-07-27;50(8):1122-1131.
Publication
released
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition
Kerrin S Small, Marijana Todorčević, Mete Civelek, et al.
Nat Genet. 2018-04-09;50(4):572-580.
Publication
released
Integrative analysis of super enhancer SNPs for type 2 diabetes
Weiping Sun, Sihong Yao, Jielong Tang, et al.
PLoS One. 2018-01-31;13(1):e0192105.
Publication
released
Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response
Kaur Alasoo, Julia Rodrigues, Subhankar Mukhopadhyay, et al.
Nat Genet. 2018-01-29;50(3):424-431.
Publication
released
Molecular and functional variation in iPSC-derived sensory neurons
Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, et al.
Nat Genet. 2017-12-11;50(1):54-61.
Publication
released
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
Kaixin Zhou, Sook Wah Yee, Eric L Seiser, et al.
Nat Genet. 2016-08-08;48(9):1055-1059.
Publication
released
Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing
Joshua N. Farr, Matthew M. Roforth, Koji Fujita, et al.
PLoS One. 2015-09-24;10(9):e0138347.
URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0138347
Publication
released
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
Alfonso Buil, Andrew Anand Brown, Tuuli Lappalainen, et al.
Nat Genet. 2014-12-01;47(1):88-91.
Publication
released
Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s Disease
Samuel Morabito, Emily Miyoshi, Neethu Michael, et al.
Nat Genet. 2021-07-08;53(8):1143-1155.
Available supplemental data: website
File format: other format
URL: https://www.synapse.org/#!Synapse:syn22079621/
Data summary: All the multi-omics raw and processed data are available here
Available supplemental data: website
File format: other format
URL: http://swaruplab.bio.uci.edu/singlenucleiAD/
Data summary: The data can be accessed through online web app
Available supplemental data: website
File format: other format
URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174367
Data summary: Raw sequencing data have been deposited into the National Center for Biotechnology Information…