Showing 23 of 23 results

• Publication

  released

  A map of transcriptional heterogeneity and regulatory variation in human microglia

  Adam M. H. Young, Natsuhiko Kumasaka, Fiona Calvert, et al.

  Nat Genet. 2021-06-03;53(6):861-868.

  • doi:10.1038/s41588-021-00875-2
  • PMID:34083789
  • PMCID:PMC7610960

• Publication

  released

  The GTEx Consortium atlas of genetic regulatory effects across human tissues

  GTEx Consortium.

  Science. 2020-09-11;369(6509):1318-1330.

  • doi:10.1126/science.aaz1776
  • PMID:32913098
  • PMCID:PMC7737656

• Publication

  released

  Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines

  Elizabeth Theusch, Yii-Der I. Chen, Jerome I. Rotter, et al.

  BMC Genomics. 2020-08-12;21(1):555.

  • doi:10.1186/s12864-020-06966-4
  • PMID:32787775
  • PMCID:PMC7430882

• Publication

  released

  Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

  C.C. Robertson, J.R.J. Inshaw, S. Onengut-Gumuscu, et al.

  bioRxiv. 2020-06-20;

  • doi:10.1101/2020.06.19.158071

• Publication

  released

  Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information

  Sebastian Guelfi, Karishma D’Sa, Juan A. Botía, et al.

  Nat Commun. 2020-02-25;11(1):1041.

  • doi:10.1038/s41467-020-14483-x
  • PMID:32098967
  • PMCID:PMC7042265

• Publication

  released

  CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder

  Gabriel E. Hoffman, Jaroslav Bendl, Georgios Voloudakis, et al.

  Sci Data. 2019-09-24;6(1):180.

  • doi:10.1038/s41597-019-0183-6
  • PMID:31551426
  • PMCID:PMC6760149

• Publication

  released

  Genetic regulation of the placental transcriptome underlies birth weight and risk of childhood obesity

  Shouneng Peng, Maya A. Deyssenroth, Antonio F. Di Narzo, et al.

  PLoS Genet. 2018-12-31;14(12):e1007799.

  • doi:10.1371/journal.pgen.1007799
  • PMID:30596636
  • PMCID:PMC6329610

• Publication

  released

  Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression

  Benjamin J Schmiedel, Divya Singh, Ariel Madrigal, et al.

  Cell. 2018-11-29;175(6):1701-1715.e16.

  • doi:10.1016/j.cell.2018.10.022
  • PMID:30449622
  • PMCID:PMC6289654

• Publication

  released

  Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

  ndrew E. Jaffe, Richard E. Straub, Joo Heon Shin, et al.

  Nat Neurosci. 2018-07-26;21(8):1117-1125.

  • doi:10.1038/s41593-018-0197-y
  • PMID:30050107
  • PMCID:PMC6438700

• Publication

  released

  Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response

  Kaur Alasoo, Julia Rodrigues, Subhankar Mukhopadhyay, et al.

  Nat Genet. 2018-01-29;50(3):424-431.

  • doi:10.1038/s41588-018-0046-7
  • PMID:29379200
  • PMCID:PMC6548559

• Publication

  released

  Molecular and functional variation in iPSC-derived sensory neurons

  Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, et al.

  Nat Genet. 2017-12-11;50(1):54-61.

  • doi:10.1038/s41588-017-0005-8
  • PMID:29229984
  • PMCID:PMC5742539

• Publication

  released

  Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes

  Jeremy R B Newman, Ana Conesa, Matthew Mika, et al.

  Genome Res. 2017-11-01;27(11):1807-1815.

  • doi:10.1101/gr.217984.116
  • PMCID:PMC5668939
  • PMID:29025893

• Publication

  released

  C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis

  Kaido Lepik, Tarmo Annilo, Viktorija Kukuškina, et al.

  PLoS Comput Biol. 2017-09-18;13(9):e1005766.

  • doi:10.1371/journal.pcbi.1005766
  • PMID:28922377
  • PMCID:PMC5609773

• Publication

  released

  An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

  Bernard Ng, Charles C White, Hans-Ulrich Klein, et al.

  Nat Neurosci. 2017-09-04;20(10):1418-1426.

  • doi:10.1038/nn.4632
  • PMID:28869584
  • PMCID:PMC5785926

• Publication

  released

  iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types

  Athanasia D Panopoulos, Matteo D'Antonio, Paola Benaglio, et al.

  Stem Cell Reports. 2017-04-11;8(4):1086-1100.

  • doi:10.1016/j.stemcr.2017.03.012
  • PMID:28410642
  • PMCID:PMC5390244

• Publication

  released

  Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci

  Evanthia E Pashos, YoSon Park, Xiao Wang, et al.

  Cell Stem Cell. 2017-04-06;20(4):558-570.e10.

  • doi:10.1016/j.stem.2017.03.017
  • PMID:28388432
  • PMCID:PMC5476422

• Publication

  released

  Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

  Rob J W Arts, Boris Novakovic, Rob Ter Horst, et al.

  Cell Metab. 2016-12-13;24(6):807-819.

  • doi:10.1016/j.cmet.2016.10.008
  • PMID:27866838
  • PMCID:PMC5742541

• Publication

  released

  Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

  Marco De Simone, Alberto Arrigoni, Grazisa Rossetti, et al.

  Immunity. 2016-11-15;45(5):1135-1147.

  • doi:10.1016/j.immuni.2016.10.021
  • PMID:27851914
  • PMCID:PMC5119953

• Publication

  released

  CD8 + T Cells from Human Neonates Are Biased toward an Innate Immune Response

  Ariel O Galindo-Albarrán, Oscar H López-Portales, Darely Y Gutiérrez-Reyna, et al.

  Cell Rep. 2016-11-15;17(8):2151-2160.

  • doi:10.1016/j.celrep.2016.10.056
  • PMID:27851975

• Publication

  released

  Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens

  Yohann Nédélec, Joaquín Sanz, Golshid Baharian, et al.

  Cell. 2016-10-20;167(3):657-669.e21.

  • doi:10.1016/j.cell.2016.09.025
  • PMID:27768889

• Publication

  released

  Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins

  Alfonso Buil, Andrew Anand Brown, Tuuli Lappalainen, et al.

  Nat Genet. 2014-12-01;47(1):88-91.

  • doi:10.1038/ng.3162
  • PMID:25436857
  • PMCID:PMC4643454

• Publication

  released

  Transcriptome and genome sequencing uncovers functional variation in humans

  Tuuli Lappalainen, Michael Sammeth, Marc R Friedländer, et al.

  Nature. 2013-09-26;501(7468):506-11.

  • doi:10.1038/nature12531
  • PMID:24037378
  • PMCID:PMC3918453

• Publication

  released

  Passive and active DNA methylation and the interplay with genetic variation in gene regulation

  Maria Gutierrez-Arcelus, Tuuli Lappalainen, Stephen B Montgomery, et al.

  Elife. 2013-06-04;2:e00523.

  • doi:10.7554/eLife.00523
  • PMID:23755361
  • PMCID:PMC3673336