March 2021 Data Release

February 27, 2021

Our latest data release has 2679 annotations and 802 assays from tissues and cell types related to diabetes, diabetic complications,              cardiovascular disease, musculoskeletal disease and many other common diseases.

        Annotations

Publication  Annotation Type
Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci accessible chromatin & gene expression
Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk accessible chromatin
Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density accessible chromatin
Expanded encyclopaedias of DNA elements in the human and mouse genomes candidate regulatory regions
Index and biological spectrum of human DNase I hypersensitive sites representative DNase hypersensitivity sites
Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits eQTL
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D eQTL
Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle eQTL
Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing  gene expression
Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits gene expression
Single Cell RNA Sequencing of Human Liver Reveals Distinct Intrahepatic Macrophage Populations gene expression
Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: primary outcomes gene expression
Methylome and transcriptome maps of human visceral and subcutaneous adipocytes reveal key epigenetic differences at developmental genes gene expression
Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis gene expression
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells gene expression
Cardiomyocyte Gene Programs Encoding Morphological and Functional Signatures in Cardiac Hypertrophy and Failure gene expression
A Single-nucleus RNA-sequencing Pipeline to Decipher the Molecular Anatomy and Pathophysiology of Human Kidneys gene expression
A temporal transcriptome and methylome in human embryonic stem cell-derived cardiomyocytes identifies novel regulators of early cardiac development gene expression
Single-cell Transcriptomics Reveals Gene Expression Dynamics of Human Fetal Kidney Development gene expression

Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease

 gene expression
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator gene expression
Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density gene expression

 

Experiments

Publication title Assay Nickname
Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci ATAC-seq
Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk ATAC-seq
Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: primary outcomes ATAC-seq
Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density ATAC-seq
Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci ChIP-seq
HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II ChIP-seq
Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing total RNA-seq
Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci total RNA-seq
Single Cell RNA Sequencing of Human Liver Reveals Distinct Intrahepatic Macrophage Populations single cell RNA-seq
Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: primary outcomes total RNA-seq
Methylome and transcriptome maps of human visceral and subcutaneous adipocytes reveal key epigenetic differences at developmental genes total RNA-seq
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells total RNA-seq
A temporal transcriptome and methylome in human embryonic stem cell-derived cardiomyocytes identifies novel regulators of early cardiac development total RNA-seq
Single-cell Transcriptomics Reveals Gene Expression Dynamics of Human Fetal Kidney Development single cell RNA-seq
Mapping Human Pluripotent-to-Cardiomyocyte Differentiation: Methylomes, Transcriptomes, and Exon DNA Methylation "Memories" total RNA-seq
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator total RNA-seq
Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density total RNA-seq
pCHi-C

All data are free and accessible for use. Please refer to our Data Use Policy for any questions. For questions    about Diabetes Epienome Atlas data, please email t2depigenome.help@gmail.com.