January 2022 Data Release

 We are pleased to release common metabolic disease relevant datasets:

Single cell chromatin accessibility atlas of ~1.2M cCREs in 222 human cell types dataset includes snATAC assay, accessible chromatin, target gene prediction and single cell embeddings

Type 1 Diabetes eQTL studies

• Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression

• iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types

• Molecular and functional variation in iPSC-derived sensory neurons

• Transcriptome and genome sequencing uncovers functional variation in humans

• Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

• Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response

• Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

• C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis

• Genetic regulation of the placental transcriptome underlies birth weight and risk of childhood obesity

• Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information

• Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci

• An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

• CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder

• Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells

• Passive and active DNA methylation and the interplay with genetic variation in gene regulation

• Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens

• Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines

•  The GTEx Consortium atlas of genetic regulatory effects across human tissues

• Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle

• Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins

• A map of transcriptional heterogeneity and regulatory variation in human microglia