A single-cell atlas of chromatin accessibility in the human genome
Cell. 2021-11-08;S0092-8674(21):01279-4.
- Abstract
- Current catalogs of regulatory sequences in the human genome are still incomplete and lack cell type resolution. To profile the activity of gene regulatory elements in diverse cell types and tissues in the human body, we applied single-cell chromatin accessibility assays to 30 adult human tissue types from multiple donors. We integrated these datasets with single-cell chromatin accessibility data from 15 fetal tissue types to reveal the status of open chromatin for approximately 1.2 million candidate cis-regulatory elements (cCREs) in 222 distinct cell types comprised of >1.3 million nuclei. We used these chromatin accessibility maps to delineate cell type-specificity of fetal and adult human cCREs and to systematically interpret the noncoding variants associated with complex human traits and diseases. This rich resource provides a foundation for the analysis of gene regulatory programs in human cell types across tissues, life stages, and organ systems.
- Consortium data used in this publication
- GEO: GSE184462. Other data used in this paper: sci-ATAC-seq data of human lung samples: dbGaP: phs001961; sci-ATAC-seq data of human heart samples: dbGaP: phs002204; sci-ATAC-seq data of human islet samples: GEO: GSE160472; sci-ATAC-seq data of human fetal tissues: https://descartes.brotmanbaty.org/bbi/human-chromatin-during-development/, dbGaP: phs002003
- Datasets
- DSR838CLG, DSR861HQN, DSR157ZRL, DSR987PCG, DSR858VQN, DSR959HLG, DSR853JCR, DSR585OMP, DSR436AKV, DSR413LRE, DSR002AWQ, DSR406MHM, DSR391UPT, DSR026SHS, DSR530GKK, DSR276TNF, DSR362JWP, DSR626BWU, DSR054HJS, DSR139UUG, DSR244DHJ, DSR570UBU, DSR662AOW, DSR678WWH, DSR903BJH, DSR419PGV, DSR609IPL, DSR269ZBF, DSR621GBJ, DSR181PDQ, DSR237XFF, DSR978SWA, DSR212PJR, DSR586QAY, DSR429JAF, DSR095TEU, DSR796CHH, DSR990DJH, DSR629RBK, DSR273VIV, DSR189CMU, DSR023CGI, DSR550PNN, DSR695XNH, DSR929UEX, DSR484DFA, DSR363ZOF, DSR586GIJ, DSR767ZHU, DSR314DTK, DSR114HTO, DSR596HRI, DSR339UCD, DSR585PBU, DSR553KLU, DSR114OHW, DSR143LGZ, DSR995HIR, DSR482QLY, DSR812RPT, DSR093KJS, DSR540TPR, DSR864AEY, DSR347CWT, DSR183KLM, DSR564IUS, DSR292ZQO, DSR698JKQ, DSR947VGN, DSR100TUS, DSR787MRF, DSR992KZC, DSR510QEM, DSR315JBQ, DSR989BFJ, DSR883SCA, DSR372XPV, DSR508KIM, DSR116GJM, DSR960EYD, DSR509HZN, DSR240ZZJ, DSR645RVD, DSR790PBA, DSR569JCK, DSR330JKD, DSR250BPY, DSR883ZYM, DSR886LLJ, DSR563FEN, DSR055OFM, DSR229UTS, DSR265CYQ, DSR197TLO, DSR222ZCJ, DSR905BUW, DSR079COZ, DSR101GFB, DSR885PKK, DSR032XBN, DSR674GFZ, DSR418GJK, DSR631SFI, DSR034JHZ, DSR347BSL, DSR657LBX, DSR983RIG, DSR241LRD, DSR909NHI, DSR647WJP, DSR629PEX, DSR425PLE, DSR450ION, DSR217ZJA, DSR093JYI, DSR682BNM, DSR170WEV, DSR497FWT, DSR620GTS, DSR794GWA, DSR450JSU, DSR550JNH, DSR209GDO, DSR326TXQ, DSR044AFP, DSR722AXI, DSR287GAP, DSR741VJV, DSR111GKW, DSR186LXU, DSR779LRI, DSR465DEB, DSR815KSN, DSR981ZFF, DSR760OPB, DSR891WWK, DSR577CUE, DSR101HMU, DSR347TWG, DSR892AFO, DSR958BVX, DSR222MBS, DSR584RYA, DSR274TCU, DSR008OBQ, DSR806IKQ, DSR569WTI, DSR600VCB, DSR447QUE, DSR911YQY, DSR843GFB, DSR820LCR, DSR269MUO, DSR579NBW, DSR929WAB, DSR528BFD, DSR581KHL, DSR107LCL, DSR157VWX, DSR356XOM, DSR337QFE, DSR771KJE, DSR858CQC, DSR067ONR, DSR659PSK, DSR900EIM, DSR799KLF, DSR084ACR, DSR774OBV, DSR919NQU, DSR562HUD, DSR427DYD, DSR383SMR, DSR874ZPI, DSR651KLN, DSR492XEZ, DSR245LTB, DSR221MTY, DSR416UAZ, DSR542FSB, DSR883CIB, DSR340ZSY, DSR804BRE, DSR149VNA, DSR681CET, DSR074SNG, DSR171WWO, DSR616QDE, DSR044JLK, DSR173UGN, DSR973TTL, DSR555WIM, DSR022KDW, DSR526MXF, DSR869KAP, DSR168DKM, DSR086BPP, DSR116URN, DSR550ZEJ, DSR459YTN, DSR894JTL, DSR367IUH, DSR876HDK, DSR441RLT, DSR300AWQ, DSR536AKW, DSR687UAM, DSR975JOZ, DSR663ZZL, DSR530GKX, DSR279PTE, DSR411KFU, DSR680BYM, DSR473YDZ, DSR552LZW, DSR058FXX, DSR261HLL, DSR607AWO, DSR470SUP, DSR940UYQ, DSR686IZQ, DSR564ZHK, DSR041TBN, DSR922IZF, DSR410PLO, DSR426ULS, DSR065NWH, DSR182RBF, DSR146SQD, DSR915OZA, DSR923OSI, DSR775ZRO, DSR588HKS, DSR563FTC, DSR571UAN, DSR111VBL, DSR451TRZ, DSR855IQO, DSR063DIM, DSR993POQ, DSR101JAH, DSR124FWF, DSR329RNA, DSR771TGI, DSR926GJY, DSR905LLL, DSR659KQD, DSR015DAN, DSR267UWF, DSR795LNM, DSR923ULB, DSR803ULZ, DSR263AKI, DSR291BPF, DSR913WND, DSR460FXP, DSR255QVL, DSR885FFE, DSR342UQG, DSR105WQB, DSR302ZYB, DSR802OCO, DSR907XMT, DSR085EEN, DSR734CMY, DSR277AWO, DSR825WFK, DSR611CKC, DSR595RQO, DSR418HFM, DSR121IWB, DSR165IBQ, DSR282OSN, DSR244BGI, DSR212MAT, DSR362NSI, DSR166KFM, DSR335RXF, DSR943ZIF, DSR385FIQ, DSR681TKD, DSR246QUC, DSR451QZS, DSR266AZC, DSR689WCE, DSR539VEP, DSR990AWB, DSR114GRY, DSR154LWM, DSR743RKT, DSR612PVM, DSR521DBF, DSR108ZJF, DSR894ZCR, DSR632ISB, DSR666BUF, DSR107HEF, DSR619FXG, DSR263RIW, DSR460HFO, DSR712FIM, DSR283LYA, DSR738TYF, DSR572LFU, DSR614LWW, DSR354WKD, DSR040UFQ, DSR097VJH, DSR920UVL, DSR772RSP, DSR392SPL, DSR855OBU, DSR770VNH, DSR953FNM, DSR483TPA, DSR814KVL, DSR124RVB, DSR281ALV, DSR960EIK, DSR385ZLJ, DSR513MXE, DSR738CKV, DSR784CEX, DSR838KCD, DSR091GRF, DSR786GAR, DSR550FOW, DSR430IHA, DSR220CDK, DSR232VYZ, DSR018YPM, DSR846PJC, DSR962GMB, DSR355QJQ
Related data
- Available data
- website
- File format
- other format
- Data summary
- sci-ATAC-seq data of human lung samples: dbGaP: phs001961
- Available data
- website
- File format
- other format
- Data summary
- sci-ATAC-seq data of human heart samples: dbGaP: phs002204
- Available data
- website
- File format
- other format
- Data summary
- sci-ATAC-seq data of human islet samples: GEO: GSE160472
- Available data
- website
- File format
- other format
- Data summary
- sci-ATAC-seq data of human fetal tissues: https://descartes.brotmanbaty.org/bbi/human-chromatin-during-development/, dbGaP: phs002003 publication 1
- Available data
- website
- File format
- other format
- Data summary
- sci-ATAC-seq data of human fetal tissues: https://descartes.brotmanbaty.org/bbi/human-chromatin-during-development/, dbGaP: phs002003 publication 2
- Available data
- website
- File format
- other format
- Data summary
- sci-ATAC-seq data of human fetal tissues: https://descartes.brotmanbaty.org/bbi/human-chromatin-during-development/, dbGaP: phs002003
- Available data
- website
- File format
- other format
- Data summary
- Human chromatin accessibility during development