Showing 12 of 265 results

• Publication

  released

  An encyclopedia of human enhancer-gene regulatory interactions

  Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, et al.

  Nature. 2026-07-15;

  • PMID:42457959
  • doi:10.1038/s41586-026-10781-4

• Publication

  released

  Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2

  Sheridan H Littleton, Khanh B Trang, Christina M Volpe, et al.

  Cell Genomics. 2024-05-08;

  • doi:10.1101/2023.08.21.553157
  • PMID:37662342
  • PMCID:PMC10473629

  Data summary: Hi-C, RNA-seq, ATAC-seq, single-nucleus RNA-seq, and single-nucleus ATAC-seq data have been…See more

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241592

  Data summary: Raw and processed Hi-C data GEO: GSE241592

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241050

  Data summary: Raw and processed RNA-seq data GEO: GSE241050

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241591

  Data summary: Raw and processed ATAC-seq data GEO: GSE241591

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241594

  Data summary: Raw and processed single-nucleus RNA-seq data GEO: GSE241594

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241593

  Data summary: Raw and processed single-nucleus ATAC-seq data GEO: GSE241593;

• Publication

  released

  Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

  Nicole E Kramer, Philip Coryell, Susan D'Costa, et al.

  bioRvix. 2024-05-05;

  • doi:10.1101/2024.05.05.592567

• Publication

  released

  Human skeletal muscle aging atlas

  Veronika R. Kedlian, Yaning Wang, Tianliang Liu, et al.

  Nature Aging. 2024-04-15;

  • PMID:38622407
  • doi:10.1038/s43587-024-00613-3

  URL: https://www.muscleageingcellatlas.org

  Data summary: The processed data objects generated within this study are available for browsing

  URL: https://doi.org/10.7272/Q65X273X

  Data summary: Raw sequencing data for the newly generated libraries have been deposited to ArrayExpress…See more

  Data summary: Mouse datasets were obtained from GSE110878, GSE138707, GSE134540, GSE143476, GSE149590 and…See more

  Data summary: All other data supporting the findings of this study are available from the corresponding authors…See more

  URL: https://github.com/Teichlab/SKM_ageing_atlas

  Data summary: Code availability: All custom notebooks and scripts used in this study have been deposited to

• Publication

  released

  Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes

  Norbert Bittner, Chenfu Shi, Danyun Zhao, et al.

  Ann Rheum Dis. 2024-03-13;:ard-2023-224945.

  • PMID:38479789
  • doi:10.1136/ard-2023-224945

• Publication

  released

  An integrated map of cell type-specific gene expression in pancreatic islets

  Ruth M Elgamal, Parul Kudtarkar, Rebecca L Melton, et al.

  Diabetes. 2023-15-08;(db230130)

  • PMID:37582230
  • doi:10.2337/db23-0130

• Publication

  released

  Population-scale skeletal muscle single-nucleus multi-omic profiling reveals extensive context specific genetic regulation

  Arushi Varshney Arushi Varshney, Nandini Manickam, Peter Orchard, et al.

  bioRxiv. 2023-12-15;

  • PMID:38168419
  • PMCID:PMC10760134
  • doi:10.1101/2023.12.15.571696

  URL: https://www.biorxiv.org/content/10.1101/2023.12.15.571696v2

• Publication

  released

  Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits

  Sarah M Brotman, Anniina Oravilahti, Jonathan D Rosen, et al.

  Diabetes. 2023-11-01;72(11):1707-1718.

  • doi:10.2337/db23-0365
  • PMID:37647564
  • PMCID:PMC10588284

• Publication

  released

  Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions

  Renhe Luo, Jielin Yan, Jin Woo Oh, et al.

  at Genet. 2023-07-24;55(8):1336-1346.

  • doi:10.1038/s41588-023-01450-7
  • PMID:37488417

  Available supplemental data: website

  Data summary: The parental HUES8 hESC line was obtained from Harvard University under a material transfer…See more

• Publication

  released

  Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes

  Kristina M. Garske, Asha Kar, Caroline Comenho, et al.

  Nat Commun. 2023-07-14;14(1):4214.

  • doi:10.1038/s41467-023-39919-y
  • PMID:37452040
  • PMCID:PMC10349101

• Publication

  released

  Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture

  Linda Kachuri, Angel C. Y. Mak, Donglei Hu, et al.

  Nat Genet. 2023-05-25;55(6):952-963.

  • PMID:37231098
  • doi:10.1038/s41588-023-01377-z
  • PMCID:PMC10260401

• Publication

  released

  Lineage-specific differences and regulatory networks governing human chondrocyte development

  Daniel Richard, Steven Pregizer, Divya Venkatasubramanian, et al.

  Elife. 2023-03-15;15:12:e79925

  • doi:10.7554/eLife.79925
  • PMID:36920035
  • PMCID:PMC10069868