Search – Common Metabolic Diseases Genome Atlas

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Publication
released
Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants
Thomsen SK, Ceroni A, van de Bunt M, et al.
December 2016;(65(12)):3805-3811.
- PMID:27554474
- doi:10.2337/db16-0361
Publication
released
Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition
Mohammadjavad Kahlani, Larry Mesner, Vedavathi Madhu, et al.
bioRxiv. 2026-02-16;(Preprint)
Publication
released
GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density
Mitchell Conery, James A. Pippin, Yadav Wagley, et al.
Genome Biology. 2025-10-03;26(1):331.
Publication
released
Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits
Kevin W Currin, Hannah J Perrin, Gautam K Pandey, et al.
Genome Res. 2025-05-20;
- doi:10.1101/gr.279741.124
- PMID:40393811
Publication
released
A comprehensive spatio-cellular map of the human hypothalamus
John A. Tadross, Lukas Steuernagel, Georgina K. C. Dowsett, et al.
Nature. 2025-02-05;639(8055):708-716.
URL: https://www.nature.com/articles/s41586-024-08504-8
Publication
released
Response splicing QTLs in primary human chondrocytes identifies putative osteoarthritis risk genes
Seyoun Byun, Philip Coryell, Nicole Kramer, et al.
bioRxiv. 2024-11-12;
- doi:10.1101/2024.11.11.622754
Publication
released
Multimodal cell atlas of the ageing human skeletal muscle
Yiwei Lai, Ignacio Ramírez-Pardo, Joan Isern, et al.
Nature. 2024-04-22;
- PMID:38649488
- doi:10.1038/s41586-024-07348-6
Data summary: All raw data have been deposited to CNGB Nucleotide Sequence Archive (CNP0004394, CNP0004395,…
URL: https://db.cngb.org/cdcp/hlma/
Data summary: All processed data are available at the Human Muscle Ageing Cell Atlas database.
URL: https://github.com/MGI-tech-bioinformatics/DNBelab_C_Series_HT_scRNA-analysis-software
Data summary: All data were analysed using standard programs and packages, as described in the Methods. Custom…
URL: https://github.com/123anjuan/HMA
Data summary: Analysis of the generated data82.
Publication
released
Human skeletal muscle aging atlas
Veronika R. Kedlian, Yaning Wang, Tianliang Liu, et al.
Nature Aging. 2024-04-15;
- PMID:38622407
- doi:10.1038/s43587-024-00613-3
URL: https://www.muscleageingcellatlas.org
Data summary: The processed data objects generated within this study are available for browsing
URL: https://doi.org/10.7272/Q65X273X
Data summary: Raw sequencing data for the newly generated libraries have been deposited to ArrayExpress…
Data summary: Mouse datasets were obtained from GSE110878, GSE138707, GSE134540, GSE143476, GSE149590 and…
Data summary: All other data supporting the findings of this study are available from the corresponding authors…
URL: https://github.com/Teichlab/SKM_ageing_atlas
Data summary: Code availability: All custom notebooks and scripts used in this study have been deposited to
Publication
released
Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes
Norbert Bittner, Chenfu Shi, Danyun Zhao, et al.
Ann Rheum Dis. 2024-03-13;:ard-2023-224945.
- PMID:38479789
- doi:10.1136/ard-2023-224945
Publication
released
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes
Fan Zhang, Anna Helena Jonsson, Aparna Nathan, et al.
Nature. 2023-11-08;623(7987):616-624.
URL: https://doi.org/10.7303/syn52297840
Data summary: CITE-seq single-cell expression matrices and sequencing and bulk expression matrices are available…
URL: https://arkportal.synapse.org/Explore/Datasets/DetailsPage?id=syn52297840
Data summary: Associated genotype and clinical data are available through the Arthritis and Autoimmune and…
URL: https://immunogenomics.io/ampra2/
Data summary: A cell browser website is available to visualize our data and results.
Data summary: AMP Phase 1 single-cell data from ref. 8 are available on Immport (SDY998). PEAC clinical trial…
URL: https://github.com/Immunogenomics/RA_Atlas_CITEseq/
Data summary: The source code for the analyses is available at GitHub
URL: https://zenodo.org/record/8118599
Data summary: The source code for the analyses is available at zenodo
Publication
released
Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits
Sarah M Brotman, Anniina Oravilahti, Jonathan D Rosen, et al.
Diabetes. 2023-11-01;72(11):1707-1718.
Publication
released
Genome-wide analysis of the interplay between chromatin-associated RNA and 3D genome organization in human cells
Riccardo Calandrelli, Xingzhao We, John Lalith Charles Richard, et al.
Nat Commun. 2023-10-16;14(1):6519.
Available supplemental data: website
URL: https://data.4dnucleome.org
Data summary: All high-throughput data supporting the current study have been deposited on the 4D Nucleome Data…
Available supplemental data: website
URL: https://github.com/Zhong-Lab-UCSD/RNA3Dgenome-code-repository
Data summary: The codes used for the analysis have been deposited and made publicly available on GitHub at…
Publication
released
A comparative atlas of single-cell chromatin accessibility in the human brain
Yang Eric Li, Sebastian Preissl, Michael Miller, et al.
Science. 2023-10-13;382(6667)
Publication
released
Plasma proteomic associations with genetics and health in the UK Biobank
Benjamin B Sun, Joshua Chiou, Matthew Traylor, et al.
Nature. 2023-10-04;622(7982):329-338.
URL: http://ukb-ppp.gwas.eu
Data summary: Proteo-genomic results and summary association data are available through an interactive portal.
URL: https://www.ukbiobank.ac.uk/enable-your-research
Data summary: Underlying NPX measures are available through the UK Biobank Research Analysis Portal.
URL: https://biobank.ndph.ox.ac.uk/showcase/label.cgi?id=1839
Data summary: UKB has catalogued the dataset in Category 1839, under ‘Field 30900’, described in greater detail…
Publication
released
An atlas of healthy and injured cell states and niches in the human kidney
Blue B. Lake, Rajasree Menon, Seth Winfree, et al.
Nature. 2023-07-19;619(7970):585-594.
URL: https://www.nature.com/articles/s41586-023-05769-3
Publication
released
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
Katia K. Mattis, Nicole A. J. Krentz, Christoph Metzendorf, et al.
Diabetologia. 2023-01-12;
- doi:10.1007/s00125-022-05856-6
- PMID:36633628

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Showing 16 of 269 results