Showing 25 of 82 results

• Publication

  released

  Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants

  Thomsen SK, Ceroni A, van de Bunt M, et al.

  December 2016;(65(12)):3805-3811.

  • PMID:27554474
  • doi:10.2337/db16-0361

• Publication

  released

  Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2

  Sheridan H Littleton, Khanh B Trang, Christina M Volpe, et al.

  Cell Genomics. 2024-05-08;

  • doi:10.1101/2023.08.21.553157
  • PMID:37662342
  • PMCID:PMC10473629

  Data summary: Hi-C, RNA-seq, ATAC-seq, single-nucleus RNA-seq, and single-nucleus ATAC-seq data have been…See more

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241592

  Data summary: Raw and processed Hi-C data GEO: GSE241592

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241050

  Data summary: Raw and processed RNA-seq data GEO: GSE241050

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241591

  Data summary: Raw and processed ATAC-seq data GEO: GSE241591

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241594

  Data summary: Raw and processed single-nucleus RNA-seq data GEO: GSE241594

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE241593

  Data summary: Raw and processed single-nucleus ATAC-seq data GEO: GSE241593;

• Publication

  released

  Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes

  Norbert Bittner, Chenfu Shi, Danyun Zhao, et al.

  Ann Rheum Dis. 2024-03-13;:ard-2023-224945.

  • PMID:38479789
  • doi:10.1136/ard-2023-224945

• Publication

  released

  An integrated map of cell type-specific gene expression in pancreatic islets

  Ruth M Elgamal, Parul Kudtarkar, Rebecca L Melton, et al.

  Diabetes. 2023-15-08;(db230130)

  • PMID:37582230
  • doi:10.2337/db23-0130

• Publication

  released

  Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

  Katia K. Mattis, Nicole A. J. Krentz, Christoph Metzendorf, et al.

  Diabetologia. 2023-01-12;

  • doi:10.1007/s00125-022-05856-6
  • PMID:36633628

• Publication

  released

  Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines

  Paola Benaglio, Han Zhu, Mei-Lin Okino, et al.

  Cell Genomics. 2022-12-14;2(12):100214.

  • doi:10.1016/j.xgen.2022.100214
  • PMID:36778047
  • PMCID:PMC9903835

• Publication

  released

  Long-range chromosomal interactions increase and mark repressed gene expression during adipogenesis

  Kristina M Garske, Caroline Comenho, David Z Pan, et al.

  Epigenetics. 2022-12-01;17(13):1849-1862.

  Available supplemental data: website

  File format: other format

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE129574

  Data summary: Assay for transposase accessible chromatin (ATAC) -seq libraries were produced from human primary…See more

• Publication

  released

  Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution

  Charles A Herring, Rebecca K Simmons, Saskia Freytag, et al.

  Cell. 2022-10-31;185(23):4428-4447.

  • doi:10.1016/j.cell.2022.09.039
  • PMID:36318921

  Available supplemental data: website

  File format: other format

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE168408

  Data summary: Single-nuclei RNA-seq and single-nuclei ATAC-seq data have been deposited at GEO under accession…See more

  Available supplemental data: website

  URL: http://brain.listerlab.org/

  Data summary: Accompanying interactive browsers for this study are available at http://brain.listerlab.org.

  Available supplemental data: website

  URL: http://development.psychencode.org/

  Data summary: All data for the Velmeshev et al. study is publicly available through the Sequence Read Archive,…See more

  Available supplemental data: website

  URL: https://www.sciencedirect.com/science/article/pii/S0092867422012582?via%3Dihub#sec4.1

  Data summary: All original code has been deposited at Zenodo and is publicly available as of the date of…See more

  Available supplemental data: website

  URL: https://www.sciencedirect.com/science/article/pii/S0092867422012582?via%3Dihub#sec4.2.1

  Data summary: Any additional information required to reanalyze the data reported in this work paper is available…See more

• Publication

  released

  Genetic regulation of RNA splicing in human pancreatic islets

  Goutham Atla, Silvia Bonàs-Guarch, Mirabai Cuenca-Ardura, et al.

  Genome Biol. 2022-09-15;23(1):196.

  • doi:10.1186/s13059-022-02757-0
  • PMID:36109769
  • PMCID:PMC9479353

  URL: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02757-0#Sec36

  Available supplemental data: website

  File format: text

  URL: https://zenodo.org/record/6546807#.Y-wbZi-B39B

• Publication

  released

  A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

  Shweta Ramdas,Jonathan Judd,Sarah E Graham,Stavroula Kanoni,Yuxuan Wang,Ida Surakka,Brandon Wenz,Shoa L Clarke,Alessandra Chesi,Andrew Wells,Konain Fatima Bhatti,Sailaja Vedantam,Thomas W Winkler,Adam E Locke,Eirini Marouli,Greg J M Zajac,Kuan-Han H Wu,Ioanna Ntalla,Qin Hui,Derek Klarin,Austin T Hilliard,Zeyuan Wang,Chao Xue,Gudmar Thorleifsson,Anna Helgadottir,Daniel F Gudbjartsson,Hilma Holm,Isleifur Olafsson,Mi Yeong Hwang,Sohee Han,Masato Akiyama,Saori Sakaue,Chikashi Terao,Masahiro Kanai,Wei Zhou,Ben M Brumpton,Humaira Rasheed,Aki S Havulinna,Yogasudha Veturi,Jennifer Allen Pacheco,Elisabeth A Rosenthal,Todd Lingren,QiPing Feng,Iftikhar J Kullo,Akira Narita,Jun Takayama,Hilary C Martin,Karen A Hunt,Bhavi Trivedi,Jeffrey Haessler,Franco Giulianini,Yuki Bradford,Jason E Miller,Archie Campbell,Kuang Lin,Iona Y Millwood,Asif Rasheed,George Hindy,Jessica D Faul,Wei Zhao,David R Weir,Constance Turman,Hongyan Huang,Mariaelisa Graff,Ananyo Choudhury,Dhriti Sengupta,Anubha Mahajan,Michael R Brown,Weihua Zhang,Ketian Yu,Ellen M Schmidt,Anita Pandit,Stefan Gustafsson,Xianyong Yin,Jian'an Luan,Jing-Hua Zhao,Fumihiko Matsuda,Hye-Mi Jang,Kyungheon Yoon,Carolina Medina-Gomez,Achilleas Pitsillides,Jouke Jan Hottenga,Andrew R Wood,Yingji Ji,Zishan Gao,Simon Haworth,Ruth E Mitchell,Jin Fang Chai,Mette Aadahl,Anne A Bjerregaard,Jie Yao,Ani Manichaikul,Wen-Jane Lee,Chao Agnes Hsiung,Helen R Warren,Julia Ramirez,Jette Bork-Jensen,Line L Kårhus,Anuj Goel,Maria Sabater-Lleal,Raymond Noordam,Pala Mauro,Floris Matteo,Aaron F McDaid,Pedro Marques-Vidal,Matthias Wielscher,Stella Trompet,Naveed Sattar,Line T Møllehave,Matthias Munz,Lingyao Zeng,Jianfeng Huang,Bin Yang,Alaitz Poveda,Azra Kurbasic,Sebastian Schönherr,Lukas Forer,Markus Scholz,Tessel E Galesloot,Jonathan P Bradfield,Sanni E Ruotsalainen,E Warwick Daw,Joseph M Zmuda,Jonathan S Mitchell,Christian Fuchsberger,Henry Christensen,Jennifer A Brody,Phuong Le,Mary F Feitosa,Mary K Wojczynski,Daiane Hemerich,Michael Preuss,Massimo Mangino,Paraskevi Christofidou,Niek Verweij,Jan W Benjamins,Jorgen Engmann,Tsao L Noah,Anurag Verma,Roderick C Slieker,Ken Sin Lo,Nuno R Zilhao,Marcus E Kleber,Graciela E Delgado,Shaofeng Huo,Daisuke D Ikeda,Hiroyuki Iha,Jian Yang,Jun Liu,Ayşe Demirkan,Hampton L Leonard,Jonathan Marten,Carina Emmel,Börge Schmidt,Laura J Smyth,Marisa Cañadas-Garre,Chaolong Wang,Masahiro Nakatochi,Andrew Wong,Nina Hutri-Kähönen,Xueling Sim,Rui Xia,Alicia Huerta-Chagoya,Juan Carlos Fernandez-Lopez,Valeriya Lyssenko,Suraj S Nongmaithem,Alagu Sankareswaran,Marguerite R Irvin,Christopher Oldmeadow,Han-Na Kim,Seungho Ryu,Paul R H J Timmers,Liubov Arbeeva,Rajkumar Dorajoo,Leslie A Lange,Gauri Prasad,Laura Lorés-Motta,Marc Pauper,Jirong Long,Xiaohui Li,Elizabeth Theusch,Fumihiko Takeuchi,Cassandra N Spracklen,Anu Loukola,Sailalitha Bollepalli,Sophie C Warner,Ya Xing Wang,Wen B Wei,Teresa Nutile,Daniela Ruggiero,Yun Ju Sung,Shufeng Chen,Fangchao Liu,Jingyun Yang,Katherine A Kentistou,Bernhard Banas,Anna Morgan,Karina Meidtner,Lawrence F Bielak,Jennifer A Smith,Prashantha Hebbar,Aliki-Eleni Farmaki,Edith Hofer,Maoxuan Lin,Maria Pina Concas,Simona Vaccargiu,Peter J van der Most,Niina Pitkänen,Brian E Cade,Sander W van der Laan,Kumaraswamy Naidu Chitrala,Stefan Weiss,Amy R Bentley,Ayo P Doumatey,Adebowale A Adeyemo,Jong Young Lee,Eva R B Petersen,Aneta A Nielsen,Hyeok Sun Choi,Maria Nethander,Sandra Freitag-Wolf,Lorraine Southam,Nigel W Rayner,Carol A Wang,Shih-Yi Lin,Jun-Sing Wang,Christian Couture,Leo-Pekka Lyytikäinen,Kjell Nikus,Gabriel Cuellar-Partida,Henrik Vestergaard,Bertha Hidalgo,Olga Giannakopoulou,Qiuyin Cai,Morgan O Obura,Jessica van Setten,Karen Y He,Hua Tang,Natalie Terzikhan,Jae Hun Shin,Rebecca D Jackson,Alexander P Reiner,Lisa Warsinger Martin,Zhengming Chen,Liming Li,Takahisa Kawaguchi,Joachim Thiery,Joshua C Bis,Lenore J Launer,Huaixing Li,Mike A Nalls,Olli T Raitakari,Sahoko Ichihara,Sarah H Wild,Christopher P Nelson,Harry Campbell,Susanne Jäger,Toru Nabika,Fahd Al-Mulla,Harri Niinikoski,Peter S Braund,Ivana Kolcic,Peter Kovacs,Tota Giardoglou,Tomohiro Katsuya,Dominique de Kleijn,Gert J de Borst,Eung Kweon Kim,Hieab H H Adams,M Arfan Ikram,Xiaofeng Zhu,Folkert W Asselbergs,Adriaan O Kraaijeveld,Joline W J Beulens,Xiao-Ou Shu,Loukianos S Rallidis,Oluf Pedersen,Torben Hansen,Paul Mitchell,Alex W Hewitt,Mika Kähönen,Louis Pérusse,Claude Bouchard,Anke Tönjes,Yii-Der Ida Chen,Craig E Pennell,Trevor A Mori,Wolfgang Lieb,Andre Franke,Claes Ohlsson,Dan Mellström,Yoon Shin Cho,Hyejin Lee,Jian-Min Yuan,Woon-Puay Koh,Sang Youl Rhee,Jeong-Taek Woo,Iris M Heid,Klaus J Stark,Martina E Zimmermann,Henry Völzke,Georg Homuth,Michele K Evans,Alan B Zonderman,Ozren Polasek,Gerard Pasterkamp,Imo E Hoefer,Susan Redline,Katja Pahkala,Albertine J Oldehinkel,Harold Snieder,Ginevra Biino,Reinhold Schmidt,Helena Schmidt,Stefania Bandinelli,George Dedoussis,Thangavel Alphonse Thanaraj,Patricia A Peyser,Norihiro Kato,Matthias B Schulze,Giorgia Girotto,Carsten A Böger,Bettina Jung,Peter K Joshi,David A Bennett,Philip L De Jager,Xiangfeng Lu,Vasiliki Mamakou,Morris Brown,Mark J Caulfield,Patricia B Munroe,Xiuqing Guo,Marina Ciullo,Jost B Jonas,Nilesh J Samani,Jaakko Kaprio,Päivi Pajukanta,Teresa Tusié-Luna,Carlos A Aguilar-Salinas,Linda S Adair,Sonny Augustin Bechayda,H Janaka de Silva,Ananda R Wickremasinghe,Ronald M Krauss,Jer-Yuarn Wu,Wei Zheng,Anneke I den Hollander,Dwaipayan Bharadwaj,Adolfo Correa,James G Wilson,Lars Lind,Chew-Kiat Heng,Amanda E Nelson,Yvonne M Golightly,James F Wilson,Brenda Penninx,Hyung-Lae Kim,John Attia,Rodney J Scott,D C Rao,Donna K Arnett,Mark Walker,Laura J Scott,Heikki A Koistinen,Giriraj R Chandak,Josep M Mercader,Clicerio Gonzalez Villalpando,Lorena Orozco,Myriam Fornage,E Shyong Tai,Rob M van Dam,Terho Lehtimäki,Nish Chaturvedi,Mitsuhiro Yokota,Jianjun Liu,Dermot F Reilly,Amy Jayne McKnight,Frank Kee,Karl-Heinz Jöckel,Mark I McCarthy,Colin N A Palmer,Veronique Vitart,Caroline Hayward,Eleanor Simonsick,Cornelia M van Duijn,Zi-Bing Jin,Fan Lu,Haretsugu Hishigaki,Xu Lin,Winfried März,Vilmundur Gudnason,Jean-Claude Tardif,Guillaume Lettre,Leen M T Hart,Petra J M Elders,Daniel J Rader,Scott M Damrauer,Meena Kumari,Mika Kivimaki,Pim van der Harst,Tim D Spector,Ruth J F Loos,Michael A Province,Esteban J Parra,Miguel Cruz,Bruce M Psaty,Ivan Brandslund,Peter P Pramstaller,Charles N Rotimi,Kaare Christensen,Samuli Ripatti,Elisabeth Widén,Hakon Hakonarson,Struan F A Grant,Lambertus Kiemeney,Jacqueline de Graaf,Markus Loeffler,Florian Kronenberg,Dongfeng Gu,Jeanette Erdmann,Heribert Schunkert,Paul W Franks,Allan Linneberg,J Wouter Jukema,Amit V Khera,Minna Männikkö,Marjo-Riitta Jarvelin,Zoltan Kutalik,Cucca Francesco,Dennis O Mook-Kanamori,Ko Willems van Dijk,Hugh Watkins,David P Strachan,Niels Grarup,Peter Sever,Neil Poulter,Wayne Huey-Herng Sheu,Jerome I Rotter,Thomas M Dantoft,Fredrik Karpe,Matt J Neville,Nicholas J Timpson,Ching-Yu Cheng,Tien-Yin Wong,Chiea Chuen Khor,Hengtong Li,Charumathi Sabanayagam,Annette Peters,Christian Gieger,Andrew T Hattersley,Nancy L Pedersen,Patrik K E Magnusson,Dorret I Boomsma,Eco J C de Geus,L Adrienne Cupples,Joyce B J van Meurs,Arfan Ikram,Mohsen Ghanbari,Penny Gordon-Larsen,Wei Huang,Young Jin Kim,Yasuharu Tabara,Nicholas J Wareham,Claudia Langenberg,Eleftheria Zeggini,Jaakko Tuomilehto,Johanna Kuusisto,Markku Laakso,Erik Ingelsson,Goncalo Abecasis,John C Chambers,Jaspal S Kooner,Paul S de Vries,Alanna C Morrison,Scott Hazelhurst,Michèle Ramsay,Kari E North,Martha Daviglus,Peter Kraft,Nicholas G Martin,John B Whitfield,Shahid Abbas,Danish Saleheen,Robin G Walters,Michael V Holmes,Corri Black,Blair H Smith,Aris Baras,Anne E Justice,Julie E Buring,Paul M Ridker,Daniel I Chasman,Charles Kooperberg,Gen Tamiya,Masayuki Yamamoto,David A van Heel,Richard C Trembath,Wei-Qi Wei,Gail P Jarvik,Bahram Namjou,M Geoffrey Hayes,Marylyn D Ritchie,Pekka Jousilahti,Veikko Salomaa,Kristian Hveem,Bjørn Olav Åsvold,Michiaki Kubo,Yoichiro Kamatani,Yukinori Okada,Yoshinori Murakami,Bong-Jo Kim,Unnur Thorsteinsdottir,Kari Stefansson,Jifeng Zhang,Y Eugene Chen,Yuk-Lam Ho,Julie A Lynch,Philip S Tsao,Kyong-Mi Chang,Kelly Cho,Christopher J O'Donnell,John M Gaziano,Peter Wilson,Karen L Mohlke,Timothy M Frayling,Joel N Hirschhorn,Sekar Kathiresan,Michael Boehnke,Million Veterans Program; Global Lipids Genetics Consortium; Struan Grant,Pradeep Natarajan,Yan V Sun,Andrew P Morris,Panos Deloukas,Gina Peloso,Themistocles L Assimes,Cristen J Willer,Xiang Zhu,Christopher D Brown.

  Am J Hum Genet. 2022-08-04;109(8):1366-1387.

  • doi:10.1016/j.ajhg.2022.06.012
  • PMID:35931049
  • PMCID:PMC9388392

• Publication

  released

  Characterizing cis-regulatory elements using single-cell epigenomics

  Sebastian Preissl, Kyle J Gaulton, Bing Ren.

  Nat Rev Genet. 2022-07-15;

  • doi:10.1038/s41576-022-00509-1
  • PMID:35840754

• Publication

  released

  Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease

  Hongbo Liu, Tomohito Doke, Dong Guo, et al.

  Nature Genetics. 2022-06-16;54:950–962.

  • PMID:35710981
  • doi:10.1038/s41588-022-01097-w

  Available supplemental data: website

  URL: https://github.com/hbliu/Kidney_Epi_Pri

  Data summary: Customized code used in the present study is available at github

  Available supplemental data: website

  URL: https://doi.org/10.5281/zenodo.6392494

  Data summary: Zenodo

• Publication

  released

  Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity

  Steven Gazal, Omer Weissbrod, Farhad Hormozdiari, et al.

  Nature Genetics. 2022-06-06;(2022)

  • doi:10.1101/2021.08.02.21261488

  URL: https://doi.org/10.5281/zenodo.6354007

  Data summary: The list of 19,995 genes, summary statistics of the 63 independent traits, training and validation…See more

  Data summary: Links for all data sets used to create S2G strategies are provided in Supplementary Table 26.

  URL: http://www.ukbiobank.ac.uk/

  Data summary: Access to the UK Biobank resource is available via application

  URL: https://www.ebi.ac.uk/gwas/api/search/downloads/full

  Data summary: The GWAS Catalog is available

  URL: https://raw.githubusercontent.com/opentargets/genetics-gold-standards/master/gold_standards/processed/gwas_gold_standards.191108.tsv

  Data summary: Open Targets SNP–gene pairs are available

  URL: https://www.dropbox.com/s/kz2c49rpm2yanf5/all_byCS_rev1.txt?dl=0

  Data summary: SNP–gene pairs from ref48 are available

  URL: https://alkesgroup.broadinstitute.org/cS2G/code

  Data summary: The code to estimate precision and recall of S2G strategies and the code to create combined S2G…See more

  URL: https://doi.org/10.5281/zenodo.6415925

  Data summary: The code to estimate precision and recall of S2G strategies and the code to create combined S2G…See more

• Publication

  released

  A mechanistic framework for cardiometabolic and coronary artery diseases

  Simon Koplev, Marcus Seldin, Katyayani Sukhavasi, et al.

  Nat Cardiovasc Res. 2022-01-12;1(1):85-100.

  • doi:10.1038/s44161-021-00009-1
  • PMID:36276926
  • PMCID:PMC9583458

  Available supplemental data: website

  URL: http://starnet.mssm.edu

  Data summary: The website was developed with a Python Flask backend and a sqlite3 database, with an application…See more

• Publication

  released

  Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits

  Peter Orchard, Nandini Manickam, Christa Ventresca, et al.

  Genome Res. 2021-11-23;31(12):2258-2275.

  • doi:10.1101/gr.268482.120
  • PMID:34815310
  • PMCID:PMC8647829

  URL: https://zenodo.org/search?page=1&size=20&q=5009200

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE178735

• Publication

  released

  A single-cell atlas of chromatin accessibility in the human genome

  Kai Zhang, James D. Hocker, Michael Miller, et al.

  Cell. 2021-11-08;S0092-8674(21):01279-4.

  • doi:10.1016/j.cell.2021.10.024
  • PMID:34774128
  • PMCID:PMC8664161

  Available supplemental data: website

  File format: other format

  URL: https://cmdga.org/publications/424edf8e-b0ab-4dfd-b61c-a68aae175e03/

  Data summary: sci-ATAC-seq data of human lung samples: dbGaP: phs001961

  Available supplemental data: website

  File format: other format

  URL: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002204.v1.p1

  Data summary: sci-ATAC-seq data of human heart samples: dbGaP: phs002204

  Available supplemental data: website

  File format: other format

  URL: https://cmdga.org/publications/1c27d047-15bc-46ac-bf94-e8881474d541/

  Data summary: sci-ATAC-seq data of human islet samples: GEO: GSE160472

  Available supplemental data: website

  File format: other format

  URL: https://cmdga.org/publications/7b1307ba-fbf9-4461-8c59-f8a65ee5379f/

  Data summary: sci-ATAC-seq data of human fetal tissues:…See more

  Available supplemental data: website

  File format: other format

  URL: https://cmdga.org/publications/1d94a4be-f51d-4f82-a84c-414193b0b2e3/

  Data summary: sci-ATAC-seq data of human fetal tissues:…See more

  Available supplemental data: website

  File format: other format

  URL: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002003.v1.p1

  Data summary: sci-ATAC-seq data of human fetal tissues:…See more

  Available supplemental data: website

  File format: other format

  URL: https://descartes.brotmanbaty.org/bbi/human-chromatin-during-development/

  Data summary: Human chromatin accessibility during development

• Publication

  released

  Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci

  Hannah J Perrin, Kevin W Currin, Swarooparani Vadlamudi, et al.

  PLoS Genet. 2021-10-26;17(10):e1009865.

  • doi:10.1371/journal.pgen.1009865
  • PMID:34699533
  • PMCID:PMC8570510

• Publication

  released

  Systematic analysis of binding of transcription factors to noncoding variants

  Jian Yan, Yunjiang Qiu, André M. Ribeiro dos Santos, et al.

  Nature. 2021-1-27;

  • doi:10.1038/s41586-021-03211-0
  • PMID:33505025

• Publication

  released

  Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution

  Alexandro E Trevino, Fabian Müller, Jimena Andersen, et al.

  Cell. 2021-09-16;184(19):5053-5069.

  • doi:10.1016/j.cell.2021.07.039
  • PMID:34390642

  Available supplemental data: website

  URL: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE162170

  Data summary: Data used for the analyses presented in this work are available under GEO: GSE162170 and on a…See more

  Available supplemental data: website

  URL: https://github.com/GreenleafLab/Brain_ASD

  Data summary: BPNet code can be found at GitHub.

  Available supplemental data: website

  URL: https://scbrainregulation.su.domains/

  Data summary: A supplementary website with references to the data, code repositories and tools for interactive…See more

• Publication

  released

  Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

  Shubham Khetan, Susan Kales, Romy Kursawe, et al.

  Nat Commun. 2021-09-02;12(1):5242.

  • doi:10.1038/s41467-021-25514-6
  • PMID:34475398
  • PMCID:PMC8413311

  URL: https://cmdga.org/publications/63f879cd-f426-4495-a12d-103fdac5867c/

  URL: https://zenodo.org/record/4974390#.YzHqHi-B39A

  Data summary: Linked to Zenodo

• Publication

  released

  A map of transcriptional heterogeneity and regulatory variation in human microglia

  Adam M. H. Young, Natsuhiko Kumasaka, Fiona Calvert, et al.

  Nat Genet. 2021-06-03;53(6):861-868.

  • doi:10.1038/s41588-021-00875-2
  • PMID:34083789
  • PMCID:PMC7610960

• Publication

  released

  Large-scale genetic association and single cell accessible chromatin mapping defines cell type-specific mechanisms of type 1 diabetes risk

  Joshua Chiou, Ryan J Geusz, Mei-Lin Okino, et al.

  Nature. 2021-05-19;594(7863):398-402.

  • doi:10.1038/s41586-021-03552-w
  • PMID:34012112

• Publication

  released

  Cardiac cell type-specific gene regulatory programs and disease risk association

  James D Hocker, Olivier B Poirion, Fugui Zhu, et al.

  Sci Adv.. 2021-05-14;7(20):eabf1444.

  • doi:10.1126/sciadv.abf1444
  • PMID:33990324
  • PMCID:PMC8121433

• Publication

  released

  Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes

  Anthony Aylward, Mei-Lin Okino, Paola Benaglio, et al.

  PLoS Genet. 2021-05-13;17(5):e1009531.

  • doi:10.1371/journal.pgen.1009531
  • PMID:33983929
  • PMCID:PMC8183998

• Publication

  released

  A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures

  Arushi Varshney, Yasuhiro Kyono, Venkateswaran Ramamoorthi Elangovan, et al.

  Diabetes. 2021-04-13;(db201087)

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